Course Description The course enables students to gain basic skills in molecular diagnosis
and karyotyping. This includes: DNA isolation and measurements, electrophoresis of nucleic …

Genomics is changing our understanding of biology. At fact, Weinstein (1998) has suggested
that all such work present, the greatest impact of genomic research has be termed “omics.” …

We used the interaction trap, a yeast genetic selection for interacting proteins, to isolate
human cyclin-dependent kinase interactor 1 (Cdi1). In yeast, Cdi1 interacts with cyclin-…

A NETWORK of interacting proteins controls the activity of cyclin-dependent kinase 2 (Cdk2)
(refs 1, 2) and governs the entry of higher eukaryotic cells into S phase. Analysis of this and …

We describe a new protein that binds to DNA and activates gene transcription in yeast. This
protein, LexA-GAL4, is a hybrid of LexA, an Escherichia coii repressor protein, and GAL4, a …

We used the interaction trap to isolate a novel human protein that specifically interacts with
Max. This protein, Mxil (for Max interactor l), contains a bHLH-Zip motif that is similar to that …

Some of the criticisms directed against this picture of systems biology are definitional. At the
margins, a great deal of science that uses of high-throughput information is indistinguishable …

Genomic data allow the large-scale manual or semi-automated assembly of metabolic
network reconstructions, which provide highly curated organism-specific knowledge bases. …

We have used the interaction trap, a yeast two-hybrid system, to identify proteins Interacting
with hairy, a basic-helix-loop-helix (bHLH) protein that represses transcription during …

Here we studied the quantitative behaviour and cell-to-cell variability of a prototypical
eukaryotic cell-fate decision system, the mating pheromone response pathway in yeast. We …