A rapid, sensitive and automated assay procedure was developed for the in vitro evaluation
of anti-HIV agents. An HTLV-I transformed T4-cell line, MT-4, which was previously shown …

Several sulfated polysaccharides (dextran sulfate, pentosan polysulfate, fucoidan, and
carrageenans) proved to be potent inhibitors for herpes simplex virus, human cytomegalovirus, …

New N-acetyl (5–8) and N-thiocarbamoyl (9–12) derivatives of 4,5-dihydropyrazole were
synthesized starting from α,β-unsaturated ketones under the effect of hydrazine hydrate and …

The (S)- and (R)-enantiomers of acyclic purine nucleoside phosphonate analogs (ie, 3-hydroxy-2-phosphonomethoxypropyl
[HPMP] derivatives, 3-fluoro-2-phosphonomethoxypropyl […

Background Plasma extracellular vesicles (EVs), especially exosome-like vesicles (ELVs),
are being increasingly explored as a source of potential noninvasive disease biomarkers. The …

Respiratory papillomatosis is a rare and often severe disease, usually localized in the larynx.
It may cause respiratory distress and even life‐threatening obstruction of the airways. …

From a series of phosphonylmethoxyalkylpurine and -pyrimidine derivatives, (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine
[(S)-HPMPC] emerged as a particularly potent and …

The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position
and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 …

… Robert Snoeck … Robert Snoeck - Laboratoire de Chimie Organique Pharmaceutique,
URA-CNRS 1111, 15 Avenue Charles Flahault, 34060 Montpellier, France, Rega Institute for …

The acyclic nucleoside phosphonate (ANP) analogues are broad-spectrum antiviral agents,
with potent and selective antiviral activity in vitro and in vivo. The prototype compounds are: (…