Since the first description in 1989 of CD4‐Fc‐fusion antagonists that inhibit human immune
deficiency virus entry into T cells, Fc‐fusion proteins have been intensely investigated for …

The human serum immunoglobulins IgG and IgA1 are produced in bone marrow and both
interact with specific cellular receptors that mediate biological events. In contrast to IgA1, the …

Abs have been shown to be protective in passive immunotherapy of tuberculous infection
using mouse experimental models. In this study, we report on the properties of a novel human …

The success of Fc-fusion bio-therapeutics has spurred the development of other Fc-fusion
products for treating and/or vaccinating against a range of diseases. We describe a method to …

Certain pathogenic bacteria express surface proteins that bind to the Fc part of human IgA
or IgG. These bacterial proteins are important as immunochemical tools and model systems, …

Recent pioneering advances in understanding how plants, insects and worms eliminate
pathogens has led to the realization that innate immunity plays a vital role in protecting humans …

Plasmodium falciparum malaria is a major cause of mortality and severe morbidity. Its
virulence is related to the parasite's ability to evade host immunity through clonal antigenic …

Fc receptors (FcRs) are crucial in the immune system; they mediate a plethora of biological
functions as diverse as antigen presentation, phagocytosis, cytotoxicity, induction of …

Cellular receptors for IgA (FcαR) mediate important protective functions. An extensive panel
of site-directed mutant IgAs was used to identify IgA residues critical for FcαR (CD89) …

The structural features of J chain required for interaction with IgA in IgA dimer assembly were
investigated by coexpression of wild-type and mutant forms of J chain with IgA1 in CHO …