Insulin was discovered more than 75 years ago, but only recently have we begun to understand
the mechanisms by which insulin promotes the uptake of glucose into cells. This review …

Insulin plays a key role in regulating a wide range of cellular processes. However, until
recently little was known about the signalling pathways that are involved in linking the insulin …

I restraining the activity of S6K, which when activated inactivates insulin receptor substrate (IRS)
function, via repression of IRS-1 gene expression and via direct phosphorylation of IRS-…

Growth factor induced activation of phosphoinositide 3-kinase and protein kinase B (PKB)
leads to increased activity of the mammalian target of rapamycin (mTOR). This subsequently …

Platelet activation at sites of vascular injury is essential for the arrest of bleeding; however,
excessive platelet accumulation at regions of atherosclerotic plaque rupture can result in the …

To gain insight into the molecular pathogenesis of obesity and specifically the role of
nutrient partitioning in the development of obesity, we overexpressed the insulin-responsive …

The mammalian target of rapamycin (mTOR) is a key regulator of protein translation.
Signaling via mTOR is increased by growth factors but decreased during nutrient deprivation. …

Recent genetic knock-in and pharmacological approaches have suggested that, of class IA
PI3Ks (phosphatidylinositol 3-kinases), it is the p110α isoform (PIK3CA) that plays the …

We have investigated the involvement of phosphoinositide (PI) 3-kinase and p70 ribosomal
protein-S6 kinase (p70s6k) in mediating insulin stimulation of glycogen synthesis in 3T3-L1 …

The members of the class II phosphoinositide 3-kinase (PI3K) family can be activated by
several stimuli, indicating that these enzymes can regulate many intracellular processes. …