Determining whether speciation and extinction rates depend on the state of a particular
character has been of long-standing interest to evolutionary biologists. To assess the effect of a …

MetaCyc ( MetaCyc.org ) is a comprehensive reference database of metabolic pathways and
enzymes from all domains of life. It contains 2749 pathways derived from more than 60 000 …

MetaCyc ( https://MetaCyc.org ) is a comprehensive reference database of metabolic pathways
and enzymes from all domains of life. It contains more than 2570 pathways derived from >…

BioCyc.org is a microbial genome Web portal that combines thousands of genomes with
additional information inferred by computer programs, imported from other databases and …

Reconstructing the phylogenetic relationships that unite all lineages (the tree of life) is a grand
challenge. The paucity of homologous character data across disparately related lineages …

Interspecific comparisons have played a prominent role in evolutionary biology at least since
the time of Charles Darwin. Since 1985, the “comparative method” has been revitalized by …

Most phylogenetically based statistical methods for the analysis of quantitative or continuously
varying phenotypic traits assume that variation within species is absent or at least …

The EcoCyc model-organism database collects and summarizes experimental data for
Escherichia coli K-12. EcoCyc is regularly updated by the manual curation of individual database …

Background There has been a considerable increase in studies investigating rates of
diversification and character evolution, with one of the promising techniques being the BiSSE …

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data,
their current form inhibits productive data analysis. The lack of a community-wide, consensus…