Within the wide spectrum of axonal diameters occurring in mammalian nerve fibers, each
class of neurons has a relatively restricted range of axonal calibers. The control of caliber has …

This study of the slow component of axonal transport was aimed at two problems: the
specific identification of polypeptides transported into the axon from the cell body, and the …

The role of neurofilaments, the intermediate filaments of nerve cells, has been conjectural.
Previous morphological studies have suggested a close relationship between neurofilament …

Oligodendroglia support axon survival and function through mechanisms independent of
myelination, and their dysfunction leads to axon degeneration in several diseases. The cause …

Myelin inhibitors, including MAG, are major impediments to CNS regeneration. However,
CNS axons of DRGs regenerate if the peripheral branch of these neurons is lesioned first. We …

Motoneurons reinnervate the distal stump at variable rates after peripheral nerve transection
and suture. In the rat femoral nerve model, reinnervation is already substantial 3 weeks …

Neuropathic pain is a refractory disease characterized by maladaptive changes in gene
transcription and translation in the sensory pathway. Long noncoding RNAs (lncRNAs) are …

Injury of axons in the peripheral nervous system (PNS) induces transcription-dependent
changes in gene expression and axonal transport that promote effective regeneration by …

We examined the differential expression of genes encoding three beta-tubulin isotypes (classes
I, II, and IV) and the 68-kDa neurofilament protein (NF68) in rat sensory neurons during …

Amyloid deposits are a characteristic feature of the senile plaques identified in the brains of
aged primates, individuals with Down's syndrome, and cases of Alzheimer's disease. The …