Over a quarter of drugs that enter clinical development fail because they are ineffective.
Growing insight into genes that influence human disease may affect how drug targets and …

Background & Aims We performed a genome-wide association study (GWAS) to identify
genetic risk factors for drug-induced liver injury (DILI) from licensed drugs without previously …

Deletions at 16p13.11 are associated with schizophrenia, mental retardation, and most
recently idiopathic generalized epilepsy. To evaluate the role of 16p13.11 deletions, as well as …

The transient receptor potential vanilloid 1 (TRPV1) is an excitatory cation channel, rather
selectively expressed in a subpopulation of nociceptive, primary sensory neurons that promote …

Drug-induced liver injury (DILI) is a leading cause of termination in drug development
programs and removal of drugs from the market; this is partially due to the inability to identify …

Some patients prescribed flucloxacillin (~ 0.01%) develop drug‐induced liver injury ( DILI ).
HLA ‐B*57:01 is an established genetic risk factor for flucloxacillin DILI . To consolidate this …

Exacerbated sensitivity to mechanical stimuli that are normally innocuous or mildly painful (mechanical
allodynia and hyperalgesia) occurs during inflammation and underlies painful …

Genome-wide identification of the mechanism of action (MoA) of small-molecule compounds
characterizing their targets, effectors, and activity modulators represents a highly relevant …

Calcitonin gene related peptide (CGRP) has been proposed to contribute to pain transmission
and inflammation and for these reasons to the mechanism of migraine. CGRP is, in fact, …

1 Hydrogen sulfide (H 2 S) is described as a mediator of diverse biological effects, and is
known to produce irritation and injury in the lung following inhalation. Recently, H 2 S has been …