User profiles for Nicolas Fossat

Nicolas FOSSAT

Assistant Professor | University of Copenhagen
Verified email at sund.ku.dk
Cited by 1241

C to U RNA editing mediated by APOBEC 1 requires RNA‐binding protein RBM 47

N Fossat, K Tourle, T Radziewic, K Barratt… - EMBO …, 2014 - embopress.org
Cytidine ( C ) to Uridine ( U ) RNA editing is a post‐transcriptional modification that is
accomplished by the deaminase APOBEC 1 and its partnership with the RNA ‐binding protein A 1 …

Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide

…, JER Grothen, NW Langvad, N Fossat… - Nature, 2023 - nature.com
RNA viruses have evolved elaborate strategies to protect their genomes, including 5′
capping. However, until now no RNA 5′ cap has been identified for hepatitis C virus 1 , 2 (HCV), …

Purkinje cells and Bergmann glia are primary targets of the TRα1 thyroid hormone receptor during mouse cerebellum postnatal development

…, F Chatonnet, F Picou, S Richard, N Fossat… - …, 2014 - journals.biologists.com
Thyroid hormone is necessary for normal development of the central nervous system, as shown
by the severe mental retardation syndrome affecting hypothyroid patients with low levels …

Temporal and spatial delineation of mouse Otx2 functions by conditional self‐knockout

N Fossat, G Chatelain, G Brun, T Lamonerie - EMBO reports, 2006 - embopress.org
To identify the independent spatial and temporal activities of the essential developmental
gene the Otx2, the germline mutation of which is lethal at embryonic day 8.5, we floxed one …

A new GFP-tagged line reveals unexpected Otx2 protein localization in retinal photoreceptors

N Fossat, C Le Greneur, F Béby, S Vincent… - BMC developmental …, 2007 - Springer
Background Dynamic monitoring of protein expression and localization is fundamental to
the understanding of biological processes. The paired-class homeodomain-containing …

Wnt signalling in mouse gastrulation and anterior development: new players in the pathway and signal output

RM Arkell, N Fossat, PPL Tam - Current opinion in genetics & development, 2013 - Elsevier
… Author links open overlay panel Ruth M Arkell 1 , Nicolas Fossat 2 3 , Patrick PL Tam 2 3 …
Images are reproduced from Fossat et al. (2011); on copyright retained by the authors. …

Functional interplay between RNA viruses and non-coding RNA in mammals

ND Damas, N Fossat, TKH Scheel - Non-coding RNA, 2019 - mdpi.com
Exploring virus–host interactions is key to understand mechanisms regulating the viral
replicative cycle and any pathological outcomes associated with infection. Whereas interactions …

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

…, P Osteil, J Studdert, ME Graham, N Fossat… - Elife, 2021 - elifesciences.org
Protein interaction is critical molecular regulatory activity underlining cellular functions and
precise cell fate choices. Using TWIST1 BioID-proximity-labeling and network propagation …

Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo

N Fossat, V Jones, PL Khoo, D Bogani… - …, 2011 - journals.biologists.com
In mouse embryos, loss of Dickkopf-1 (DKK1) activity is associated with an ectopic activation
of WNT signalling responses in the precursors of the craniofacial structures and leads to a …

Otx2 Gene Deletion in Adult Mouse Retina Induces Rapid RPE Dystrophy and Slow Photoreceptor Degeneration

F Béby, M Housset, N Fossat, C Le Greneur, F Flamant… - PloS one, 2010 - journals.plos.org
Background Many developmental genes are still active in specific tissues after development
is completed. This is the case for the homeobox gene Otx2, an essential actor of forebrain …