Type 2 diabetes (T2DM), Alzheimer’s disease (AD), and insulin resistance are age‐related
conditions and increased prevalence is of public concern. Recent research has provided …

A wealth of evidence indicates a strong link between type 2 diabetes (T2D) and
neurodegenerative diseases such as Alzheimer’s disease (AD). Although the precise mechanism …

Alzheimer’s disease (AD) and type 2 diabetes (T2D) present a significant risk to each other.
AD and T2D are characterized by deposition of cerebral amyloid‐β (Aβ) and pancreatic …

OBJECTIVE Zinc ions are essential for the formation of hexameric insulin and hormone
crystallization. A nonsynonymous single nucleotide polymorphism rs13266634 in the SLC30A8 …

Pten (phosphatase with tensin homology), a dual-specificity phosphatase, is a negative
regulator of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. Pten regulates a vast …

The functional impact of adiponectin on pancreatic beta cells is so far poorly understood.
Although adiponectin receptors (AdipoR1/2) were identified, their involvement in adiponectin-…

Changes in cellular cholesterol affect insulin secretion, and β-cell–specific deletion or loss-of-function
mutations in the cholesterol efflux transporter ATP-binding cassette transporter A1 (…

Type 2 diabetes (T2D) arises when pancreatic β-cells fail to compensate for systemic insulin
resistance with appropriate insulin secretion. However, the link between insulin resistance …

Cellular cholesterol homeostasis is important for normal β-cell function. Disruption of cholesterol
transport by decreased function of the ATP-binding cassette (ABC) transporter ABCA1 …

OBJECTIVE The ATP-binding cassette transporter A1 (ABCA1) is essential for normal insulin
secretion from β-cells. The aim of this study was to elucidate the mechanisms underlying …