How position-dependent cell fate acquisition occurs during embryogenesis is a central
question in developmental biology. To study this process, we developed a defined, high-…

Gastrulation controls the emergence of cellular diversity and axis patterning in the early
embryo. In mammals, this transformation is orchestrated by dynamic signalling centres at the …

New fundamental discoveries in stem cell biology have yielded potentially transformative
regenerative therapeutics. However, widespread implementation of stem-cell-derived …

In vitro models of postimplantation human development are valuable to the fields of regenerative
medicine and developmental biology. Here, we report characterization of a robust in …

Large cohorts of human induced pluripotent stem cells (iPSCs) from healthy donors are a
potentially powerful tool for investigating the relationship between genetic variants and cellular …

The mechanism by which morphogenetic signals engage the regulatory networks responsible
for early embryonic tissue patterning is incompletely understood. Here, we developed a …

Stem cell renewal and differentiation are regulated by interactions with the niche. Although
multiple cell populations have been identified in distinct anatomical compartments, little is …

Efforts to recapitulate haematopoiesis, a process guided by spatial and temporal inductive
signals, to generate haematopoietic progenitors from human pluripotent stem cells (hPSCs) …

Quantitative analysis of human induced pluripotent stem cell (iPSC) lines from healthy donors
is a powerful tool for uncovering the relationship between genetic variants and cellular …

The balance between stem cell renewal and differentiation is determined by the interplay
between intrinsic cellular controls and extrinsic factors presented by the microenvironment, or ‘…