Phthalazine‐based VEGFR‐2 inhibitors: Rationale, design, synthesis, in silico, ADMET profile, docking, and anticancer evaluations
F Khedr, MK Ibrahim, IH Eissa… - Archiv der …, 2021 - Wiley Online Library
In the designed compounds, a new linker was inserted in the form of fragments with verified
VEGFR‐2 inhibitory potential, including an α,β‐unsaturated ketonic fragment, pyrazole, and …
VEGFR‐2 inhibitory potential, including an α,β‐unsaturated ketonic fragment, pyrazole, and …
[1, 2, 4] Triazolo [4, 3-c] quinazoline and bis ([1, 2, 4] triazolo)[4, 3-a: 4′, 3′-c] quinazoline derived DNA intercalators: Design, synthesis, in silico ADMET profile …
In view of their DNA intercalation activities as anticancer agents, novel fifteen [1,2,4]triazolo[4,3-c]quinazoline
and bis([1,2,4]triazolo)[4,3-a:4′,3′-c]quinazoline derivatives have been …
and bis([1,2,4]triazolo)[4,3-a:4′,3′-c]quinazoline derivatives have been …
[HTML][HTML] Design, synthesis, molecular docking and anticonvulsant evaluation of novel 6-iodo-2-phenyl-3-substituted-quinazolin-4 (3H)-ones
MK Ibrahim, K El-Adl, AA Al-Karmalawy - Bulletin of Faculty of Pharmacy …, 2015 - Elsevier
A new series of 6-iodo-2-phenyl-3-substituted-quinazolin-4(3H)-one (5–12 a–b ) derivatives
were synthesized, evaluated for their anticonvulsant activity against pentylenetetrazole (PTZ)…
were synthesized, evaluated for their anticonvulsant activity against pentylenetetrazole (PTZ)…
N‐Substituted‐4‐phenylphthalazin‐1‐amine‐derived VEGFR‐2 inhibitors: Design, synthesis, molecular docking, and anticancer evaluation studies
K El‐Adl, MK Ibrahim, F Khedr… - Archiv der …, 2021 - Wiley Online Library
In accordance with the significant impetus of the discovery of potent vascular endothelial
growth factor receptor 2 (VEGFR‐2) inhibitors, herein, we report the design, synthesis, and …
growth factor receptor 2 (VEGFR‐2) inhibitors, herein, we report the design, synthesis, and …
[HTML][HTML] Design and synthesis of some novel 2-(3-methyl-2-oxoquinoxalin-1 (2H)-yl)-N-(4-(substituted) phenyl) acetamide derivatives for biological evaluation as …
MK Ibrahim, AA Abd-Elrahman, RRA Ayyad… - Bulletin of Faculty of …, 2013 - Elsevier
A new series of 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)-N-(4-substitutedphenyl)acetamides (2–15
a–c ) were designed and synthesized in order to evaluate their anticonvulsant activity. …
a–c ) were designed and synthesized in order to evaluate their anticonvulsant activity. …
Rationale, in silico docking, ADMET profile, design, synthesis and cytotoxicity evaluations of phthalazine derivatives as VEGFR-2 inhibitors and apoptosis inducers
HH Bayoumi, MK Ibrahim, MA Dahab, F Khedr… - RSC …, 2024 - pubs.rsc.org
New phthalazine derivatives as vascular endothelial growth factor receptor-2 (VEGFR-2)
inhibitors were synthesized joined to different spacers including pyrazole, α,β-unsaturated …
inhibitors were synthesized joined to different spacers including pyrazole, α,β-unsaturated …
Exploration of the VEGFR-2 inhibition activity of phthalazine derivatives: design, synthesis, cytotoxicity, ADMET, molecular docking and dynamic simulation
HH Bayoumi, MK Ibrahim, MA Dahab, F Khedr… - RSC …, 2024 - pubs.rsc.org
Novel phthalazine derivatives were designed, synthesized and evaluated against Hep G2
and MCF-7 as VEGFR-2 inhibitors. In particular, compounds 2g and 4a were found to be the …
and MCF-7 as VEGFR-2 inhibitors. In particular, compounds 2g and 4a were found to be the …
Part I: cancer in Sudan—burden, distribution, and trends breast, gynecological, and prostate cancers
…, ME Ibrahim, D Abuidris, KEH Mohamed… - Cancer …, 2015 - Wiley Online Library
Despite the growing burden of cancer worldwide, it continues to receive low priority in Africa,
across the continent and specifically in Sudan. This is due to political unrest, limited health …
across the continent and specifically in Sudan. This is due to political unrest, limited health …
Design, synthesis, in silico ADMET, docking, and antiproliferative evaluations of [1,2,4]triazolo[4,3‐c]quinazolines as classical DNA intercalators
MS Alesawy, MK Ibrahim, IH Eissa… - Archiv der …, 2022 - Wiley Online Library
Eleven novel [1,2,4]triazolo[4,3‐c]quinazolines were designed, synthesized, and evaluated
against HepG2 and HCT‐116 cells. The molecular design was performed to investigate the …
against HepG2 and HCT‐116 cells. The molecular design was performed to investigate the …
Design, synthesis, docking, and biological evaluation of some novel 5-chloro-2-substituted sulfanylbenzoxazole derivatives as anticonvulsant agents
In view of their expected anticonvulsant activity, some novel derivatives of 5-chloro-2-substituted
sulfanylbenzoxazoles (5–15f) were synthesized and evaluated for their anticonvulsant …
sulfanylbenzoxazoles (5–15f) were synthesized and evaluated for their anticonvulsant …