Climate change is already affecting Arctic species including infectious disease agents and
greater changes are expected. Some infectious diseases are already increasing but future …

These findings demonstrate the molecular mechanism of action and potent antitumor
activity of SY-1365, the first selective CDK7 inhibitor to enter clinical investigation. …

The assembly of actin monomers into filaments and networks plays vital roles throughout
eukaryotic biology, including intracellular transport, cell motility, cell division, determining …

Rab GTPases are key regulators of membrane traffic pathways within eukaryotic cells. They
are specifically activated by guanine nucleotide exchange factors (GEFs), which convert …

RNA helicase enzymes catalyze the in vivo folding and conformational re-arrangement of
RNA. DEAD-box proteins (DBPs) make up the largest family of RNA helicases and are found …

CDK7 has emerged as an exciting target in oncology due to its roles in two important processes
that are misregulated in cancer cells: cell cycle and transcription. This report describes …

CDK7 associates with the 10-subunit TFIIH complex and regulates transcription by phosphorylating
the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Few additional CDK7 …

Actin assembly, filament mechanical properties, and interactions with regulatory proteins
depend on the types and concentrations of salts in solution. Salts modulate actin through both …

Mss116 is a Saccharomyces cerevisiae mitochondrial DEAD-box RNA helicase protein that
is essential for efficient in vivo splicing of all group I and group II introns and for activation of …

To address the problem of post-traumatic stress disorder (PTSD) in severe mental illness,
the Trauma Recovery Group, a mixed gender cognitive-behavioral program, was developed …