Objective: OCD is a clinically heterogeneous condition. This heterogeneity has the potential
to reduce power in genetic, neuroimaging, and clinical trials. Despite a mounting number of …

Serum levels of inflammatory cytokines, for example, tumor necrosis factor alpha (TNFα),
interleukin-6 (IL-6), and IL-1 beta (IL-1β), are elevated in subjects with major depressive …

Background Early studies suggest that radiofrequency-based renal denervation reduces blood
pressure in patients with moderate hypertension. We investigated whether an alternative …

Study Objectives To investigate the efficacy of melatonin compared to placebo in improving
sleep parameters in patients with primary sleep disorders. Design PubMed was searched for …

Objective: Suicide is a public health crisis with limited treatment options. The authors conducted
a systematic review and individual participant data meta-analysis examining the effects …

Obsessive-compulsive disorder (OCD) is a common, debilitating neuropsychiatric illness
with complex genetic etiology. The International OCD Foundation Genetics Collaborative (…

Background: Most children with Tourette syndrome (TS) experience a marked decline in the
severity of tic symptoms during adolescence. Currently no clinical measures can predict …

Background Endovascular renal denervation reduces blood pressure in patients with mild-to-moderate
hypertension, but its efficacy in patients with true resistant hypertension has not …

One large retailer started a $1.4 billion effort to modernize its IT systems, but the project was
eventually abandoned. As the company fell behind its competitors, it initiated another project…

Background Tourette syndrome (TS) is a childhood-onset neuropsychiatric disorder that is
characterized by both motor and phonic tics. One half to two thirds of children with TS …