Streptozotocin (Streptozocin, STZ, CAS No. 18883-66-4) is a monofunctional nitrosourea
derivative isolated from Streptomyces achromogenes. It has broad spectrum antibiotic activity …

Malfunction of mismatch repair (MMR) genes produces nuclear genome instability (NGI) and
plays an important role in the origin of some hereditary and sporadic human cancers. The …

Objective: To obtain reference ranges for each of the main antioxidant enzymes (AOE) and
analyze the influence of sex, age, and cigarette smoking on AOE activity in human blood. …

Telomeres are specialized nucleoproteic complexes localized at the physical ends of linear
eukaryotic chromosomes that maintain their stability and integrity. The DNA component of …

Streptonigrin (SN, CAS no. 3930-19-6) is an aminoquinone antitumor antibiotic isolated
from cultures of Streptomyces flocculus. This compound is a member of a group of antitumor …

We analyzed 40 pairs of breast normal/cancer tissues for the presence of mitochondrial (mt)
genome instability and nuclear MSI in tumor cells. As mt, markers we used a (CA) n mt …

Bleomycin (BLM) is an antibiotic isolated from Streptomyces verticillus. It has radiomimetic
actions on DNA thus it has been widely used in clinical chemotherapy for the treatment of …

The correlation between serum levels of pituitary and thyroid hormones and the activity of two
antioxidant enzymes (AOE), catalase (CAT) and superoxide dismutase (SOD), in different …

The mechanism of chromosome banding induced by restriction endonucleases was
analyzed by measuring the amount of radioactivity extracted from [ 14 C]thymidine-labeled …

Non-protein thiols are considered radioprotectors, preventing DNA damage by ionizing
radiation. As bleomycin (BLM) is a radiomimetic agent it was proposed that thiols may prevent …