Background: Anecdotal evidence suggests that the sensitivity and specificity of a diagnostic
test may vary with disease prevalence. Our objective was to investigate the associations …

Background COVID‐19 illness is highly variable, ranging from infection with no symptoms
through to pneumonia and life‐threatening consequences. Symptoms such as fever, cough, or …

… Leeflang is supported by the Netherlands Organization for Scientific Research (NWO); project
… Critical revision of the article for important intellectual content: MMG Leeflang, J. Minion, T. …

In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was
developed. Experience, anecdotal reports, and feedback suggested areas for improvement; …

Importance Systematic reviews of diagnostic test accuracy synthesize data from primary
diagnostic studies that have evaluated the accuracy of 1 or more index tests against a reference …

Background The diagnostic challenges associated with the COVID‐19 pandemic resulted in
rapid development of diagnostic test methods for detecting SARS‐CoV‐2 infection. …

Background Accurate rapid diagnostic tests for SARS‐CoV‐2 infection would be a useful tool
to help manage the COVID‐19 pandemic. Testing strategies that use rapid antigen tests to …

Background Invasive aspergillosis is the most common life‐threatening opportunistic invasive
mycosis in immunocompromised patients. A test for invasive aspergillosis should neither …

BACKGROUND: Several studies and systematic reviews have reported results that indicate
that sensitivity and specificity may vary with prevalence. STUDY DESIGN AND SETTING: We …

More and more systematic reviews of diagnostic test accuracy studies are being published,
but they can be methodologically challenging. In this paper, the authors present some of the …