Localization accuracy of distributed inverse solutions for electric and magnetic source imaging of interictal epileptic discharges in patients with focal epilepsy

M Heers, RA Chowdhury, T Hedrich, F Dubeau… - Brain topography, 2016 - Springer
Distributed inverse solutions aim to realistically reconstruct the origin of interictal epileptic
discharges (IEDs) from noninvasively recorded electroencephalography (EEG) and …

Detection of interictal epileptiform discharges in an extended scalp EEG array and high‐density EEG—a prospective multicenter study

M Heers, S Böttcher, A Kalina, S Katletz… - …, 2022 - Wiley Online Library
Objectives High counts of averaged interictal epileptiform discharges (IEDs) are key
components of accurate interictal electric source imaging (ESI) in patients with focal epilepsy. …

Combined EEG/MEG can outperform single modality EEG or MEG source reconstruction in presurgical epilepsy diagnosis

…, M Dümpelmann, P Küpper, H Kugel, M Heers… - PloS one, 2015 - journals.plos.org
We investigated two important means for improving source reconstruction in presurgical
epilepsy diagnosis. The first investigation is about the optimal choice of the number of epileptic …

Transcutaneous vagus nerve stimulation (t‐VNS) in pharmacoresistant epilepsies: A proof of concept trial

…, F Kerling, K Kurzbuch, C Rauch, M Heers… - …, 2012 - Wiley Online Library
To elucidate, in a pilot‐study, whether noninvasive transcutaneous vagus nerve stimulation (t‐VNS)
is a safe and tolerable alternative treatment option in pharmacoresistant epilepsy. t‐…

How to record high‐frequency oscillations in epilepsy: a practical guideline

…, M Dümpelmann, T Stieglitz, A Barborica, M Heers… - …, 2017 - Wiley Online Library
Objective Technology for localizing epileptogenic brain regions plays a central role in surgical
planning. Recent improvements in acquisition and electrode technology have revealed …

Combining EEG and MEG for the reconstruction of epileptic activity using a calibrated realistic volume conductor model

Ü Aydin, J Vorwerk, P Küpper, M Heers, H Kugel… - PloS one, 2014 - journals.plos.org
To increase the reliability for the non-invasive determination of the irritative zone in presurgical
epilepsy diagnosis, we introduce here a new experimental and methodological source …

Effects of cannabidiol on brivaracetam plasma levels

KA Klotz, M Hirsch, M Heers, A Schulze‐Bonhage… - …, 2019 - Wiley Online Library
The use of cannabidiol ( CBD ) for treatment of pharmacoresistant epilepsies is increasing.
CBD is metabolized via UDP‐glucuronosyltransferase (UGT) and cytochrome 450 (CYP) …

[HTML][HTML] MEG-based identification of the epileptogenic zone in occult peri-insular epilepsy

M Heers, S Rampp, H Stefan, H Urbach, CE Elger… - Seizure, 2012 - Elsevier
INTRODUCTION: Presurgical work-ups of patients with pharmacoresistant epileptic seizures
can require multiple diagnostic methods if magnetic resonance imaging (MRI) combined …

MEG–EEG information fusion and electromagnetic source imaging: from theory to clinical application in epilepsy

RA Chowdhury, Y Zerouali, T Hedrich, M Heers… - Brain topography, 2015 - Springer
The purpose of this study is to develop and quantitatively assess whether fusion of EEG and
MEG (MEEG) data within the maximum entropy on the mean (MEM) framework increases …

[HTML][HTML] Effects of cenobamate on cognitive performance of epilepsy patients

…, G Papadopoulou, K Kravalis, M Heers… - … : European Journal of …, 2022 - Elsevier
Purpose Cenobamate (CNB) is a new antiseizure medication (ASM) for the treatment of
focal epilepsy in adults. While efficacy of CNB was confirmed in controlled clinical trials, its …