Gating of social reward by oxytocin in the ventral tegmental area

LW Hung, S Neuner, JS Polepalli, KT Beier, M Wright… - Science, 2017 - science.org
The reward generated by social interactions is critical for promoting prosocial behaviors.
Here we present evidence that oxytocin (OXT) release in the ventral tegmental area (VTA), a …

The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

LW Hung, VL Villemagne, L Cheng… - Journal of Experimental …, 2012 - rupress.org
Parkinson’s disease (PD) is a progressive, chronic disease characterized by dyskinesia,
rigidity, instability, and tremors. The disease is defined by the presence of Lewy bodies, which …

The Alzheimer's therapeutic PBT2 promotes amyloid‐β degradation and GSK3 phosphorylation via a metal chaperone activity

PJ Crouch, MS Savva, LW Hung… - Journal of …, 2011 - Wiley Online Library
J. Neurochem. (2011) 119, 220–230. Abstract Impaired metal ion homeostasis causes
synaptic dysfunction and treatments for Alzheimer’s disease (AD) that target metal ions have …

5-HT release in nucleus accumbens rescues social deficits in mouse autism model

…, BD Heifets, GA Ben-Dor, A Selimbeyoglu, LW Hung… - Nature, 2018 - nature.com
Dysfunction in prosocial interactions is a core symptom of autism spectrum disorder.
However, the neural mechanisms that underlie sociability are poorly understood, limiting the …

Oral treatment with CuII (atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic …

…, JR Williams, KM Kanninen, LW Hung… - Journal of …, 2014 - jneurosci.org
Mutations in the metallo-protein Cu/Zn-superoxide dismutase (SOD1) cause amyotrophic
lateral sclerosis (ALS) in humans and an expression level-dependent phenotype in transgenic …

Diacetylbis (N (4)-methylthiosemicarbazonato) copper (II)(CuII (atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic …

CPW Soon, PS Donnelly, BJ Turner, LW Hung… - Journal of Biological …, 2011 - jbc.org
Amyotrophic lateral sclerosis (ALS) is a progressive paralyzing disease characterized by
tissue oxidative damage and motor neuron degeneration. This study investigated the in vivo …

Development of a platinum complex as an anti-amyloid agent for the therapy of Alzheimer's disease.

VB Kenche, LW Hung, K Perez, I Volitakes… - Angewandte …, 2013 - search.ebscohost.com
Alzheimer s disease (AD) is an age-related neurodegenerative disease. Its pathological
indicators include extracellular amyloid plaques, the main constituent of which is the amyloid β-…

Multi-Q: a fully automated tool for multiplexed protein quantitation

WT Lin, WN Hung, YH Yian, KP Wu… - Journal of Proteome …, 2006 - ACS Publications
The iTRAQ labeling method combined with shotgun proteomic techniques represents a new
dimension in multiplexed quantitation for relative protein expression measurement in …

… 18F-fluorodeoxyglucose positron emission tomography to detect para-aortic lymph nodal metastasis in advanced cervical cancer with negative computed tomography …

WC Lin, YC Hung, LS Yeh, CH Kao, RF Yen… - Gynecologic …, 2003 - Elsevier
OBJECTIVE: In advanced cervical cancer, it has been reported that progression-free survival
is significantly related to para-aortic lymph node metastasis. Computed tomography (CT) …

Morphology and organization of tissue cells in 3D microenvironment of monodisperse foam scaffolds

J Lin, W Lin, W Hong, W Hung, SH Nowotarski… - Soft Matter, 2011 - pubs.rsc.org
Here we demonstrate an efficient method to fabricate large-domain monodisperse foam
scaffolds made of gelatin for 3D cell culture. We tested three distinct tissue cell types cultured in …