The complement system serves an important role in clearance of pathogens, immune complexes,
and apoptotic cells present in the circulation. Complement fragments deposited on the …

B cell immunotherapy has emerged as a mainstay in the treatment of lymphomas and
autoimmune diseases. Although the microenvironment has recently been demonstrated to play …

Interleukin 17C (IL-17C) is a member of the IL-17 family that is selectively induced in epithelia
by bacterial challenge and inflammatory stimuli. Here we show that IL-17C functioned in a …

Background Etrolizumab is a humanised monoclonal antibody that selectively binds the β7
subunit of the heterodimeric integrins α4β7 and αEβ7. We aimed to assess etrolizumab in …

The connection between an altered gut microbiota and metabolic disorders such as obesity,
diabetes, and cardiovascular disease is well established 1 , 2 . Defects in preserving the …

Protein tyrosine kinases and phosphatases cooperate to regulate normal immune cell
function. We examined the role of PEST domain–enriched tyrosine phosphatase (PEP) in …

Crohn’s disease is a debilitating inflammatory bowel disease (IBD) that can involve the entire
digestive tract. A single-nucleotide polymorphism (SNP) encoding a missense variant in …

Bruton's tyrosine kinase (Btk) is a therapeutic target for rheumatoid arthritis, but the cellular
and molecular mechanisms by which Btk mediates inflammation are poorly understood. Here …

Introduction Rheumatoid arthritis (RA) is a complex and clinically heterogeneous autoimmune
disease. Currently, the relationship between pathogenic molecular drivers of disease in …

Objective: To investigate differential intestinal gene expression in patients with ulcerative
colitis and in controls. Design: Genome-wide expression study (41 058 expression sequence …