Caspase-8 is the initiator caspase of extrinsic apoptosis 1 , 2 and inhibits necroptosis
mediated by RIPK3 and MLKL. Accordingly, caspase-8 deficiency in mice causes embryonic …

In the normal quiescent vasculature, only 0.01% of endothelial cells ( EC s) are proliferating.
However, this proportion increases dramatically following the angiogenic switch during …

Simple Summary Esophageal cancer is one of the top ten most deadly cancers. Even when
diagnosed in a curable stage, patients prognosis poor. One of the parameters that is very …

The cytosolic appearance and propagation of bacteria cause overwhelming cellular stress
responses that induce apoptosis under normal conditions. Therefore, successful bacterial …

Cellular inhibitor of apoptosis proteins (cIAPs) are RING‐containing E3 ubiquitin ligases that
ubiquitylate receptor‐interacting protein kinase 1 (RIPK1) to regulate TNF signalling. Here, …

Introduction Transthoracic esophagectomy is a highly complex and sophisticated procedure
with high morbidity rates and a significant mortality. Surgical access has consistently …

Elevated expression of the X‐linked inhibitor of apoptosis protein (XIAP) has been frequently
reported in malignant melanoma suggesting that XIAP renders apoptosis resistance and …

Background Robotic-assisted minimally invasive esophagectomy (RAMIE) was first introduced
in 2003 and has since then shown to significantly improve the postoperative course. …

Anastomotic leakage (AL) after esophagectomy is the most impactful complication after
esophagectomy. Ischemic conditioning (ISCON) of the stomach >14 days prior to …

Angiogenesis describes the formation of blood vessels from an existing vascular network.
Anti-angiogenic drugs that target tumor blood vessels have become standard of care in many …