TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT
J Zhuang, Q Lu, B Shen, X Huang, L Shen, X Zheng… - Scientific reports, 2015 - nature.com
Urinary bladder cancer (UBC) patients at muscle invasive stage have poor clinical outcome,
due to high propensity for metastasis. Cancer-associated fibroblasts (CAFs), one of the …
due to high propensity for metastasis. Cancer-associated fibroblasts (CAFs), one of the …
Cancer-associated fibroblast–derived miR-146a-5p generates a niche that promotes bladder cancer stemness and chemoresistance
J Zhuang, L Shen, M Li, J Sun, J Hao, J Li, Z Zhu… - Cancer …, 2023 - aacrjournals.org
The tumor–stromal cross-talk mediated by cancer-associated fibroblast–derived miR-146a-5p
fosters cancer stem cell niche formation and cancer stemness to drive chemoresistance in …
fosters cancer stem cell niche formation and cancer stemness to drive chemoresistance in …
TGFβ1 promotes gemcitabine resistance through regulating the LncRNA-LET/NF90/miR-145 signaling axis in bladder cancer
J Zhuang, L Shen, L Yang, X Huang, Q Lu, Y Cui… - …, 2017 - pmc.ncbi.nlm.nih.gov
High tumor recurrence is frequently observed in patients with urinary bladder cancers (UBCs),
with the need for biomarkers of prognosis and drug response. Chemoresistance and …
with the need for biomarkers of prognosis and drug response. Chemoresistance and …
Wnt7a activates canonical Wnt signaling, promotes bladder cancer cell invasion, and is suppressed by miR-370-3p
Once urinary bladder cancer (UBC) develops into muscle-invasive bladder cancer, its mortality
rate increases dramatically. However, the molecular mechanisms of UBC invasion and …
rate increases dramatically. However, the molecular mechanisms of UBC invasion and …
The detection of prostate cancer with magnetic resonance imaging-targeted prostate biopsies is superior with the transperineal vs the transrectal approach. A …
…, M Valerio, P Gontero, H Guo, J Zhuang… - The Journal of …, 2022 - auajournals.org
Purpose: Our aim was to evaluate whether transperineal (TP) MRI-targeted prostate biopsy (TBx)
may improve the detection of clinically significant prostate cancer (csPCa), defined as …
may improve the detection of clinically significant prostate cancer (csPCa), defined as …
Self-assembled tumor-targeting hyaluronic acid nanoparticles for photothermal ablation in orthotopic bladder cancer
Bladder cancer is one of the most frequent malignancies in the urinary system. Radical
cystectomy is inevitable when bladder cancer progresses to a muscle-invasive disease. However…
cystectomy is inevitable when bladder cancer progresses to a muscle-invasive disease. However…
Risk stratification of patients candidate to radical prostatectomy based on clinical and multiparametric magnetic resonance imaging parameters: development and …
…, T Soeterik, M Roumiguiè, L Afferi, J Zhuang… - European Urology, 2022 - Elsevier
Background Despite the key importance of magnetic resonance imaging (MRI) parameters,
risk classification systems for biochemical recurrence (BCR) in prostate cancer (PCa) …
risk classification systems for biochemical recurrence (BCR) in prostate cancer (PCa) …
Multi-cohort validation of Ascore: an anoikis-based prognostic signature for predicting disease progression and immunotherapy response in bladder cancer
…, W Diao, M Ding, Y Fu, H Guo, W Zhao, J Zhuang - Molecular Cancer, 2024 - Springer
Bladder cancer ranks as the 10th most common cancer worldwide, with deteriorating
prognosis as the disease advances. While immune checkpoint inhibitors (ICIs) have shown …
prognosis as the disease advances. While immune checkpoint inhibitors (ICIs) have shown …
Membrane-associated RING-CH 7 inhibits stem-like capacities of bladder cancer cells by interacting with nucleotide-binding oligomerization domain containing 1
J Zhuang, L Zhang, S Zhang, Z Zhang, T Xie, W Zhao… - Cell & Bioscience, 2024 - Springer
Background Cancer stem-like capacities are major factors contributing to unfavorable
prognosis. However, the associated molecular mechanisms underlying cancer stem-like cells (…
prognosis. However, the associated molecular mechanisms underlying cancer stem-like cells (…
Transperineal freehand multiparametric MRI fusion targeted biopsies under local anaesthesia for prostate cancer diagnosis: a multicentre prospective study of 1014 …
G Marra, J Zhuang, M Beltrami, G Calleris… - BJU …, 2021 - Wiley Online Library
Objective To assess the outcomes of multiparametric magnetic resonance imaging (mpMRI)
transperineal targeted fusion biopsy (TPFBx) under local anaesthesia. Patients and …
transperineal targeted fusion biopsy (TPFBx) under local anaesthesia. Patients and …