D-Serine (D-Ser) is an endogenous co-agonist for NMDA receptors and regulates neurotransmission
and synaptic plasticity in the forebrain. D-Ser is also found in the cerebellum during …

Neuronal networks are dynamically modified by selective synapse pruning during development
and adulthood. However, how certain connections win the competition with others and …

The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin,
and reporter expression in the mouse nervous system. However, we report varying …

Ionotropic glutamate receptor (iGluR) family members are integrated into supramolecular
complexes that modulate their location and function at excitatory synapses. However, a lack of …

Long-term depression (LTD) of AMPA-type glutamate receptor (AMPA receptor)-mediated
synaptic transmission has been proposed as a cellular substrate for learning and memory. …

Excitatory synapses are formed and matured by the cooperative actions of synaptic organizers,
such as neurexins (Nrxns), neuroligins (Nlgns), LRRTMs, and Cbln1. Recent super-…

Synapse formation is achieved by various synaptic organizers. Although this process is
highly regulated by neuronal activity, the underlying molecular mechanisms remain largely …

The cerebellum is thought to be involved in cognitive functions in addition to its well
established role in motor coordination and motor learning in humans. Cerebellin 1 (Cbln1) is …

The δ2 glutamate receptor (GluRδ2) is predominantly expressed in Purkinje cells and plays
crucial roles in cerebellar functions: GluRδ2 −/− mice display ataxia and impaired motor …

The δ2 glutamate receptor (GluRδ2; GluD2), which is predominantly expressed on postsynaptic
sites at parallel fiber (PF)–Purkinje cell synapses in the cerebellum, plays two crucial …