Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction
…, Y Endoh, C Okumura, Y Okuhara, J Magae… - Biochemical and …, 2003 - Elsevier
To confirm whether human cancer-induced stromal cells are derived from bone marrow, bone
marrow (BM) cells obtained from β-galactosidase transgenic and recombination activating …
marrow (BM) cells obtained from β-galactosidase transgenic and recombination activating …
In vivo characterization of bone marrow–derived fibroblasts recruited into fibrotic lesions
…, K Sugiyama, T Ito, T Hasebe, Y Endoh, J Magae… - Stem …, 2005 - academic.oup.com
Fibroblasts, which are widely distributed and play a key part in tissue fibrosis, are phenotypically
and functionally heterogeneous. Recent studies reported that bone marrow can be a …
and functionally heterogeneous. Recent studies reported that bone marrow can be a …
Anti‐inflammatory effect of ascochlorin in LPS‐stimulated RAW 264.7 macrophage cells is accompanied with the down‐regulation of iNOS, COX‐2 and …
…, HW Chang, YC Lee, BS Kang, J Magae… - Journal of cellular …, 2016 - Wiley Online Library
A natural compound C 23 H 32 O 4 Cl, ascochlorin (ASC) isolated from an incomplete fungus,
Ascochyta viciae has been known to have several biological activities as an antibiotic, …
Ascochyta viciae has been known to have several biological activities as an antibiotic, …
Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members
E2F is a family of transcription factors implicated in the regulation of genes required for
progression through G 1 and entry into the S phase. The transcriptionally active forms of E2F are …
progression through G 1 and entry into the S phase. The transcriptionally active forms of E2F are …
[HTML][HTML] Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of …
Deregulated activation of oncogenic transcription factors such as signal transducer and
activator of transcription 3 (STAT3) plays a pivotal role in proliferation and survival of …
activator of transcription 3 (STAT3) plays a pivotal role in proliferation and survival of …
Costunolide and dehydrocostus lactone as inhibitors of killing function of cytotoxic T lymphocytes
…, M Uramoto, M Ando, K Arao, J Magae… - Bioscience …, 1995 - academic.oup.com
Costunolide and dehydrocostus lactone were isolated from an extract of mokko (Saussurea
lappa Clarke) as inhibitors of killing activity of cytotoxic T lymphocytes (CTL). Mokko lactone …
lappa Clarke) as inhibitors of killing activity of cytotoxic T lymphocytes (CTL). Mokko lactone …
Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK-and Ap1-dependent mechanisms
…, TS Lee, IS Lee, NG Park, H Nakajima, J Magae… - …, 2007 - academic.oup.com
The expression of matrix metalloproteinase-9 (MMP-9) has been implicated in the invasion
and metastasis of cancer cells. Here, we found that an antitumor antibiotic, ascofuranone, …
and metastasis of cancer cells. Here, we found that an antitumor antibiotic, ascofuranone, …
Ascochlorin enhances the sensitivity of doxorubicin leading to the reversal of epithelial-to-mesenchymal transition in hepatocellular carcinoma
Increasing evidence has indicated that epithelial-to-mesenchymal transition (EMT) at the
advanced stage of liver cancer not only has the ability to self-renew and progress cancer, but …
advanced stage of liver cancer not only has the ability to self-renew and progress cancer, but …
Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway …
SH Hong, KK Park, J Magae, K Ando, TS Lee… - Journal of Biological …, 2005 - jbc.org
The expression of matrix metalloproteinases (MMPs) has been implicated in the invasion
and metastasis of cancer cells. Here we examined the effect of ascochlorin, a prenyl-phenol …
and metastasis of cancer cells. Here we examined the effect of ascochlorin, a prenyl-phenol …
Acidification is essential for maintaining the structure and function of lytic granules of CTL. Effect of concanamycin A, an inhibitor of vacuolar type H (+)-ATPase, on …
T Kataoka, K Takaku, J Magae… - … (Baltimore, Md.: 1950 …, 1994 - journals.aai.org
An inhibitor of vacuolar type H(+)-ATPase, concanamycin A (CMA), inhibited the specific
cytolytic activity of a CD8+ CTL clone, OE4. The inhibitory effect was observed when the effector …
cytolytic activity of a CD8+ CTL clone, OE4. The inhibitory effect was observed when the effector …