Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts.
Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein …

Peptidoglycan is the major structural constituent of the bacterial cell wall, forming a meshwork
outside the cytoplasmic membrane that maintains cell shape and prevents lysis. In Gram-…

The functional spectrum of a secretion system is defined by its substrates. Here we analyzed
the secretomes of Pseudomonas aeruginosa mutants altered in regulation of the Hcp …

The type VI secretion system (T6SS) mediates interactions between a broad range of Gram-negative
bacterial species. Recent studies have led to a substantial increase in the number …

Secreted proteins are crucial to the arsenal of bacterial pathogens. Although optimal activity
of these proteins is likely to require precise regulation of release, the signalling events that …

Bacterial toxins represent a vast reservoir of biochemical diversity that can be repurposed for
biomedical applications. Such proteins include a group of predicted interbacterial toxins of …

Type VI secretion (T6S) influences the composition of microbial communities by catalyzing
the delivery of toxins between adjacent bacterial cells. Here, we demonstrate that a T6S …

Membranes allow the compartmentalization of biochemical processes and are therefore
fundamental to life. The conservation of the cellular membrane, combined with its accessibility …

… We thank members of the Mougous and Cascales laboratories and Pacome-Aude Lavieille
… LeRoux M, Vollmer W, Mougous JD, 2011; Type VI secretion delivers bacteriolytic effectors …

Bacteria that live in the environment have evolved pathways specialized to defend against
eukaryotic organisms or other bacteria. In this manuscript, we systematically examined the …