Motivation: Molecular biotechnology now makes it possible to build elaborate systems
models, but the systems biology community needs information standards if models are to be …

Robustness, the ability to maintain performance in the face of perturbations and uncertainty,
is a long-recognized key property of living systems. Owing to intimate links to cellular …

Network-based definitions of biochemical pathways have emerged in recent years. These
pathway definitions insist on the balanced use of a whole network of biochemical reactions. …

The relationship between structure, function and regulation in complex cellular networks is
a still largely open question 1 , 2 , 3 . Systems biology aims to explain this relationship by …

Abstract Systems biology iteratively combines experimentation with mathematical modeling.
However, limited mechanistic knowledge, conflicting hypotheses and scarce experimental …

Motivation: Elementary flux modes (EFMs)—non-decomposable minimal pathways—are
commonly accepted tools for metabolic network analysis under steady state conditions. Valid …

Robustness, a relative insensitivity to perturbations, is a key characteristic of living cells.
However, the specific structural characteristics that are responsible for robust performance are …

Systems biology aims at an understanding of the genotype–phenotype relations brought
about by cellular networks. Mathematical models as formal representations are central for …

Adaptation of cells to environmental changes requires dynamic interactions between
metabolic and regulatory networks, but studies typically address only one or a few layers of …

Abstract Systems biology has experienced dramatic growth in the number, size, and
complexity of computational models. To reproduce simulation results and reuse models, …