Background Diverse datasets, including genomic, transcriptomic, proteomic and metabolomic
data, are becoming readily available for specific organisms. There is currently a need to …

Genome-scale models of Escherichia coli K-12 MG1655 metabolism have been able to predict
growth phenotypes in most, but not all, defined growth environments. Here we introduce …

An updated genome‐scale reconstruction of the metabolic network in Escherichia coli K‐12
MG1655 is presented. This updated metabolic reconstruction includes: (1) an alignment with …

Our information about the gene content of organisms continues to grow as more genomes
are sequenced and gene products are characterized. Sequence-based annotation efforts …

Bacteria of the genus Shewanella are known for their versatile electron-accepting capacities,
which allow them to couple the decomposition of organic matter to the reduction of the …

Microbial cells operate under governing constraints that limit their range of possible
functions. With the availability of annotated genome sequences, it has become possible to …

The flood of high-throughput biological data has led to the expectation that computational (or
in silico) models can be used to direct biological discovery, enabling biologists to reconcile …

Contrary to the proinflammatory role of mast cells in allergic disorders, the results obtained
in this study establish that mast cells are essential in CD4 + CD25 + Foxp3 + regulatory T (T …

BACKGROUND: Peripheral blood eosinophilia and lung mucosal eosinophil infiltration are
hallmarks of bronchial asthma. IL-5 is a critical cytokine for eosinophil maturation, survival, …

Background. Respiratory syncytial virus (RSV) and influenza virus are common causes of
infantile lower respiratory tract infection (LRTI). It is widely believed that both viral replication …