The tumour-necrosis-factor-family molecule osteoprotegerin ligand (OPGL; also known as
TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation factor …

Osteoprotegerin (OPG) is a secreted protein that inhibits osteoclast formation. In this study
the physiological role of OPG is investigated by generating OPG-deficient mice. Adolescent …

A receptor that mediates osteoprotegerin ligand (OPGL)-induced osteoclast differentiation
and activation has been identified via genomic analysis of a primary osteoclast precursor cell …

Bone resorption and remodeling is an intricately controlled, physiological process that
requires the function of osteoclasts. The processes governing both the differentiation and …

We have generated RANK (receptor activator of NF-κB) nullizygous mice to determine the
molecular genetic interactions between osteoprotegerin, osteoprotegerin ligand, and RANK …

Introduction: Sclerosteosis is a rare high bone mass genetic disorder in humans caused by
inactivating mutations in SOST, the gene encoding sclerostin. Based on these data, …

Bone metastases are a frequent complication of many cancers that result in severe disease
burden and pain 1 , 2 , 3 . Since the late nineteenth century, it has been thought that the …

The signalling thresholds of antigen receptors and co-stimulatory receptors determine
immunity or tolerance to self molecules 1 . Changes in co-stimulatory pathways can lead to …

TALL-1/Blys/BAFF is a member of the tumor necrosis factor (TNF) ligand superfamily that is
functionally involved in B cell proliferation. Here, we describe B cell hyperplasia and …

High systemic levels of osteoprotegerin (OPG) in OPG transgenic mice cause osteopetrosis
with normal tooth eruption and bone elongation and inhibit the development and activity of …