User profiles for Ian A. Simpson

Ian A. Simpson

Archaeology, Durham University
Verified email at durham.ac.uk
Cited by 6932

The facilitative glucose transporter GLUT3: 20 years of distinction

IA Simpson, D Dwyer, D Malide… - American Journal …, 2008 - journals.physiology.org
Glucose metabolism is vital to most mammalian cells, and the passage of glucose across cell
membranes is facilitated by a family of integral membrane transporter proteins, the GLUTs. …

Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease

IA Simpson, KR Chundu, T Davies‐Hill… - Annals of Neurology …, 1994 - Wiley Online Library
Glucose metabolism is depressed in the temporal and parietal regions of the cortex in patients
with Alzheimer's disease. We measured the concentrations of two glucose transporters, …

Diabetic retinopathy: seeing beyond glucose-induced microvascular disease

…, PG Quinn, L Sandirasegarane, IA Simpson… - Diabetes, 2006 - diabetesjournals.org
Diabetic retinopathy remains a frightening prospect to patients and frustrates physicians.
Destruction of damaged retina by photocoagulation remains the primary treatment nearly 50 …

Crossing the thresholds: human ecology and historical patterns of landscape degradation

IA Simpson, AJ Dugmore, A Thomson, O Vésteinsson - Catena, 2001 - Elsevier
In discussions of landscape sensitivity, human activities have generally been regarded as
external forces contributing to landscape change, with a focus on the impacts of cultivation …

Supply and demand in cerebral energy metabolism: the role of nutrient transporters

IA Simpson, A Carruthers… - Journal of Cerebral …, 2007 - journals.sagepub.com
Glucose is the obligate energetic fuel for the mammalian brain, and most studies of cerebral
energy metabolism assume that the majority of cerebral glucose utilization fuels neuronal …

Glucose transporter proteins in brain: delivery of glucose to neurons and glia

SJ Vannucci, F Maher, IA Simpson - Glia, 1997 - Wiley Online Library
Glucose is the principle energy source for the mammalian brain. Delivery of glucose from the
blood to the brain requires transport across the endothelial cells of the blood‐brain barrier …

Glucose transporter proteins in brain

F Maher, SJ Vannucci, IA Simpson - The FASEB Journal, 1994 - Wiley Online Library
Glucose is the principal energy source for the mammalian brain. The presence of glucose
transport proteins is essential to supply glucose to the neurons and glia within the brain. At …

[HTML][HTML] Structure of the blood–brain barrier and its role in the transport of amino acids

RA Hawkins, RL O'Kane, IA Simpson, JR Vina - The Journal of nutrition, 2006 - Elsevier
Brain capillary endothelial cells form the blood–brain barrier (BBB). They are connected by
extensive tight junctions, and are polarized into luminal (blood-facing) and abluminal (brain-…

Archaeological assessment reveals Earth's early transformation through land use

…, P Schmidt, P Sebillaud, O Seitsonen, IA Simpson… - Science, 2019 - science.org
Environmentally transformative human use of land accelerated with the emergence of
agriculture, but the extent, trajectory, and implications of these early changes are not well …

Fuel resource utilisation in landscapes of settlement

IA Simpson, O Vésteinsson, WP Adderley… - Journal of …, 2003 - Elsevier
One little understood aspect of the settlement and colonisation of Iceland is fuel resource
use. In this paper we identify fuel ash residues from temporally constrained middens at two …