DNA from 61 unrelated patients with adenomatous polyposis coli (APC) was examined for
mutations in three genes@ Pi, SRP79, and DP2. 5) located within a 166 kb region deleted in …

The BRAF V600E mutation has been associated with microsatellite instability and the CpG
island methylator phenotype (CIMP) in colon cancer. We evaluated a large population-based …

Small (loo-260 kb), nested deletions were characterized in DNA from two unrelated patients
with familial adenomatous polyposis coli (APC). Three candidate genes located within the …

Background & Aims: The concept of a CpG island methylator phenotype (CIMP), especially
in microsatellite stable colon cancer, is not accepted universally. We therefore evaluated a …

In the last few years there have been rapid advances in developing genetic maps for
humans, greatly enhancing our ability to localize and identify genes for inherited disorders. …

Background: Cigarette smoking has been associated with microsatellite instability in sporadic
colon cancer. Most microsatellite-unstable colon cancers have widespread methylation of …

Charcot–Marie–Tooth disease 1A (CMT1A) is a hereditary demyelinating peripheral neuropathy,
associated with a DNA duplication on chromosome 17p11.2. A related disorder in the …

Endometriosis is a common gynecological condition with complex etiology defined by the
presence of endometrial glands and stroma outside the womb. Endometriosis is a common …

It has been proposed that dietary factors such as folate, alcohol and methionine may be
associated with colon cancer because of their involvement in DNA methylation processes. Data …

Inhibitors of DNA methyltransferase, typified by 5-aza-2′-deoxycytidine (5-Aza-CdR), induce
the expression of genes transcriptionally down-regulated by de novo methylation in tumor …