I have identified an activity in crude HeLa cell extracts that satlsfles the requirements for a
human telomere terminal transfemse or telomemse. It catalyzes the addition of a 6 nucleotlde …

Normal human cells undergo a finite number of cell divisions and ultimately enter a nondividing
state called replicative senescence. It has been proposed that telomere shortening is the …

Catalytic protein subunits of telomerase from the ciliateEuplotes aediculatus and the yeast
Saccharomyces cerevisiae contain reverse transcriptase motifs. Here the homologous genes …

Primary triple-negative breast cancers (TNBCs), a tumour type defined by lack of oestrogen
receptor, progesterone receptor and ERBB2 gene amplification, represent approximately 16…

The maintenance of chromosome termini, or telomeres, requires the action of the enzyme
telomerase, as conventional DNA poly-merases cannot fully replicate the ends of linear …

Background Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis,
but the molecular events involved in this transformation have not been described. Methods …

A critical step in proteomics analysis is the optimal extraction and processing of protein
material to ensure the highest sensitivity in downstream detection. Achieving this requires a …

Mapping protein–protein interactions is an invaluable tool for understanding protein function.
Here, we report the first large‐scale study of protein–protein interactions in human cells …

Next-generation sequencing of follicular lymphoma and diffuse-large B-cell lymphoma has
revealed frequent somatic, heterozygous Y641 mutations in the histone methyltransferase …

Most normal human diploid cells have no detectable telomerase; however, expression of the
catalytic subunit of telomerase is sufficient to induce telomerase activity and, in many cases, …