[HTML][HTML] Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans

…, RH Houtkooper, T van de Weijer, GH Goossens… - Cell metabolism, 2011 - cell.com
Resveratrol is a natural compound that affects energy metabolism and mitochondrial function
and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we …

[HTML][HTML] The metabolic phenotype in obesity: fat mass, body fat distribution, and adipose tissue function

GH Goossens - Obesity facts, 2017 - karger.com
The current obesity epidemic poses a major public health issue since obesity predisposes
towards several chronic diseases. BMI and total adiposity are positively correlated with …

The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance

GH Goossens - Physiology & behavior, 2008 - Elsevier
Research of the past decade has increased our understanding of the role adipose tissue plays
in health and disease. Adipose tissue is now recognized as a highly active metabolic and …

A new framework for the diagnosis, staging and management of obesity in adults

…, JCG Halford, P Sbraccia, V Yumuk, GH Goossens - Nature Medicine, 2024 - nature.com
The European Association for the Study of Obesity presents a new framework for the
diagnosis, staging and management of obesity in adults to better align with the concept of …

Effects of gut microbiota manipulation by antibiotics on host metabolism in obese humans: a randomized double-blind placebo-controlled trial

D Reijnders, GH Goossens, GDA Hermes, EPJG Neis… - Cell metabolism, 2016 - cell.com
The gut microbiota has been implicated in obesity and cardiometabolic diseases, although
evidence in humans is scarce. We investigated how gut microbiota manipulation by …

One week of bed rest leads to substantial muscle atrophy and induces whole-body insulin resistance in the absence of skeletal muscle lipid accumulation

…, GP Holloway, A Chabowski, GH Goossens… - Diabetes, 2016 - diabetesjournals.org
Short (<10 days) periods of muscle disuse, often necessary for recovery from illness or injury,
lead to various negative health consequences. The current study investigated mechanisms …

Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and …

GH Goossens, A Bizzarri, N Venteclef, Y Essers… - Circulation, 2011 - ahajournals.org
Background— Adipose tissue (AT) dysfunction in obesity contributes to chronic, low-grade
inflammation that predisposes to type 2 diabetes mellitus and cardiovascular disease. Recent …

Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial

…, CM van der Beek, JWE Jocken, GH Goossens… - Scientific reports, 2017 - nature.com
Short-chain fatty acids (SCFA), formed by microbial fermentation, are believed to be involved
in the aetiology of obesity and diabetes. This study investigated the effects of colonic …

Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans

M Müller, MAG Hernández, GH Goossens… - Scientific reports, 2019 - nature.com
Microbial-derived short-chain fatty acids (SCFA) acetate, propionate and butyrate may
provide a link between gut microbiota and whole-body insulin sensitivity (IS). In this cross-…

[HTML][HTML] The ABCD of obesity: an EASO position statement on a diagnostic term with clinical and scientific implications

…, L Busetto, D Dicker, V Yumuk, GH Goossens… - Obesity facts, 2019 - karger.com
Obesity is a frequent, serious, complex, relapsing, and chronic disease process that represents
a major public health problem. The coining of obesity as an adiposity-based chronic …