S100A8 and S100A9 are members of the S100 family of cytoplasmic EF-hand Ca 2+ -binding
proteins and are abundantly expressed in the cytosol of neutrophils. In addition to their …

Neutrophils are the most abundant leukocytes in blood and disruption in their functions often
results in an increased risk of serious infections and inflammatory autoimmune diseases. …

Neutrophils—once considered as simple killers of pathogens and unexciting for cancer
research—are now acknowledged for their role in the process of tumorigenesis. Neutrophils are …

Therapy Induced Senescence (TIS) leads to sustained growth arrest of cancer cells. The
associated cytostasis has been shown to be reversible and cells escaping senescence further …

GEC1 protein shares high identity with GABARAP (GABA A Receptor-Associated Protein),
interacts with tubulin and GABA A receptors and is potentially involved in intracellular …

For more than two centuries now, rheumatoid arthritis (RA) is under investigation intending
to discover successful treatment. Despite decades of scientific advances, RA is still …

S100A9, a Ca 2+ -binding protein, is tightly associated to neutrophil pro-inflammatory
functions when forming a heterodimer with its S100A8 partner. Upon secretion into the …

Background Neutrophils are an important source of pro-inflammatory and immunomodulatory
cytokines. This makes neutrophils efficient drivers of interactions with immune and non-…

The release of cytokines by neutrophils constitutes an essential process in the development
of inflammation by recruiting and activating additional cells. Neutrophils are also able to …

Resistance of melanoma cells to targeted therapy (BRAF and MEK inhibitors) is a major
clinical problem and alternative treatments are sought. We describe the establishment of …