Cell-associated proteoglycans provide highly complex and sophisticated systems to control
interactions of extracellular cell matrix components and soluble ligands with the cell surface. …

The cyclical protrusion and retraction of the leading edge is a hallmark of many migrating
cells involved in processes such as development, inflammation and tumorigenesis. The …

Hemodynamic shear stresses cause endothelial cells (ECs) to polarize in the plane of the
flow. Paradoxically, under strong shear flows, ECs disassemble their primary cilia, common …

Full activity of fibroblast growth factors (FGFs) requires their internalization in addition to the
interaction with cell surface receptors. Recent studies have suggested that the …

PV1 is an endothelial-specific integral membrane glycoprotein associated with the stomatal
diaphragms of caveolae, transendothelial channels, and vesiculo-vacuolar organelles and …

Proteoglycans participate in growth factor interaction with the cell surface through their
heparan sulfate chains (HS), but it is not known if they are otherwise involved in growth factor …

We have built and characterized a magnetic clamp for reversible sealing of PDMS microfluidic
chips against cover glasses with cell cultures and a microfluidic chip for experiments on …

Syndecan-4 is a heparan sulfate-carrying core protein that has been directly implicated in
fibroblast growth factor 2 (FGF2) signaling. Recent studies have suggested that many …

Cell migration is a dynamic process involving formation of a leading edge in the direction of
migration and adhesion points from which tension is generated to move the cell body forward…

Branching morphogenesis is a key process in the formation of vascular networks. To date,
little is known regarding the molecular events regulating this process. We investigated the …