Fibroblasts can condense a hydrated collagen lattice to a tissue-like structure 1/28th the area
of the starting gel in 24 hr. The rate of the process can be regulated by varying the protein …

Living skin-equivalent grafts consisting of fibroblasts cast in collagen lattices and seeded
with epidermal cells were successfully grafted onto the donors of the cells. The grafts were …

A living-skin equivalent useful as a skin replacement and as a model system for basic studies
has been fabricated and tested extensively, it consists of two components: (1) a dermal …

Any claim to having made a skin substitute must bc tempered by a rigorous comparison with
the real thing, since skin is an organ of intricate anatomic complexity and great functional …

A strategy for developing scaffolding materials for prostheses capable of inducing tissue
regeneration is presented. It is based on knowledge of the stimuli cells need to carry out their …

A model of a blood vessel was constructed in vitro. Its multilayered structure resembled that
of an artery and it withstood physiological pressures. Electron microscopy showed that the …

IN THE application of focused ultrasound to research and therapy in neurology, two primary
problems confront us:(1) How to select dosage factors so that lesions of a standard size and …

Background: We evaluated in a canine duraplasty model how specific differences in device
physicomechanical properties, porosity, and crosslinking influenced the biological …

The technology for culture of epidermis is one of the most advanced to date for generation
of a tissue in vitro. Cultured epidermis is already used for a number of applications ranging …

Collagen biosynthesis by fibroblasts and subsequent processing and polymerization have
been studied in conventional monolayer cultures and in a new model system in vitro in which …