User profiles for Elena V. Batrakova

Elena Batrakova

Associate Professor, University of North Carolina at Chapel Hill
Verified email at email.unc.edu
Cited by 24085

Exosomes as drug delivery vehicles for Parkinson's disease therapy

…, M Sokolsky, AV Kabanov, EV Batrakova - Journal of controlled …, 2015 - Elsevier
Exosomes are naturally occurring nanosized vesicles that have attracted considerable attention
as drug delivery vehicles in the past few years. Exosomes are comprised of natural lipid …

Using exosomes, naturally-equipped nanocarriers, for drug delivery

EV Batrakova, MS Kim - Journal of Controlled Release, 2015 - Elsevier
Exosomes offer distinct advantages that uniquely position them as highly effective drug
carriers. Comprised of cellular membranes with multiple adhesive proteins on their surface, …

Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers

EV Batrakova, AV Kabanov - Journal of controlled release, 2008 - Elsevier
Polymer nanomaterials have sparked a considerable interest as vehicles used for
diagnostic and therapeutic agents; research in nanomedicine has not only become a frontier …

Hypersensitization of multidrug resistant human ovarian carcinoma cells by pluronic P85 block copolymer

VY Alakhov, EY Moskaleva, EV Batrakova… - Bioconjugate …, 1996 - ACS Publications
The chemosensitizing effects of Pluronic P85 block copolymer were studied using two human
ovarian carcinoma sublines: the glycoprotein P (P-gp) multidrug resistant (MDR) SKVLB …

Pluronic® block copolymers as novel polymer therapeutics for drug and gene delivery

AV Kabanov, EV Batrakova, VY Alakhov - Journal of controlled release, 2002 - Elsevier
Pluronic ® block copolymers are found to be an efficient drug delivery system with multiple
effects. The incorporation of drugs into the core of the micelles formed by Pluronic ® results in …

Pluronic® block copolymers for overcoming drug resistance in cancer

AV Kabanov, EV Batrakova, VY Alakhov - Advanced drug delivery reviews, 2002 - Elsevier
Pluronic ® block copolymers have been used extensively in a variety of pharmaceutical
formulations including delivery of low molecular mass drugs and polypeptides. This review …

Mechanism of pluronic effect on P-glycoprotein efflux system in blood-brain barrier: contributions of energy depletion and membrane fluidization

EV Batrakova, S Li, SV Vinogradov, VY Alakhov… - The Journal of …, 2001 - Elsevier
Pluronic block copolymer, P85, inhibits the P-glycoprotein (Pgp) drug efflux system and
increases the permeability of a broad spectrum of drugs in the blood-brain barrier (BBB). This …

Optimal structure requirements for pluronic block copolymers in modifying P-glycoprotein drug efflux transporter activity in bovine brain microvessel endothelial cells

EV Batrakova, SHU Li, VY Alakhov, DW Miller… - The Journal of …, 2003 - Elsevier
Pluronic block copolymer P85 was shown to inhibit the P-glycoprotein (Pgp) drug efflux system
and to increase the permeability of a broad spectrum of drugs in the blood-brain barrier (…

A Macrophage− Nanozyme delivery system for Parkinson's disease

EV Batrakova, S Li, AD Reynolds, RL Mosley… - Bioconjugate …, 2007 - ACS Publications
Selective delivery of antioxidants to the substantia nigra pars compacta (SNpc) during
Parkinson's disease (PD) can potentially attenuate oxidative stress and as such increase survival …

Pluronic P85 increases permeability of a broad spectrum of drugs in polarized BBMEC and Caco-2 cell monolayers

EV Batrakova, S Li, DW Miller, AV Kabanov - Pharmaceutical research, 1999 - Springer
Purpose. Previous studies demonstrated that inhibition of P glycoprotein (P-gp) by Pluronic
P85 (P85) block copolymer increases apical (AP) to basolateral (BL) transport of rhodamine …