Background Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases
the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin …

Background The contribution of various risk factors to the burden of stroke worldwide is
unknown, particularly in countries of low and middle income. We aimed to establish the …

Background Three different glucagon-like peptide-1 (GLP-1) receptor agonists reduce
cardiovascular outcomes in people with type 2 diabetes at high cardiovascular risk with high …

Background Small trials have suggested that radial access for percutaneous coronary
intervention (PCI) reduces vascular complications and bleeding compared with femoral access. …

Background Stroke is a leading cause of death and disability, especially in low-income and
middle-income countries. We sought to quantify the importance of potentially modifiable risk …

Background India has the highest burden of acute coronary syndromes in the world, yet little
is known about the treatments and outcomes of these diseases. We aimed to document the …

Background Previous trials have shown that the use of statins to lower cholesterol reduces
the risk of cardiovascular events among persons without cardiovascular disease. Those trials …

BACKGROUND:: Myocardial injury after noncardiac surgery (MINS) was defined as prognostically
relevant myocardial injury due to ischemia that occurs during or within 30 days after …

Background There is substantial variability in the perioperative administration of aspirin in
patients undergoing noncardiac surgery, both among patients who are already on an aspirin …

Background Air pollution is a major planetary health risk, with India estimated to have some
of the worst levels globally. To inform action at subnational levels in India, we estimated the …