Background Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles
(MSC-EVs) hold promise as a disease modifying treatment in osteoarthritis (OA). Obesity, …

In animal models, joint degeneration observed in response to obesogenic diet varies in
nature and severity. In this study, we compare joint damage in Sprague Dawley and Wistar-Han …

Introduction: Obesogenic diets aggravate osteoarthritis (OA) by inducing low-grade systemic
inflammation, and diet composition may affect OA severity. Here, we investigated the effect …

… The authors wish to thank Dr Tony Ades for his helpful comments on an earlier version of
this manuscript and Dr Jan van Bergen for additional data on PID rates in recent years. This …

Background Glioblastoma is most commonly reported in the second (pediatric form) and
seventh (adult form) decade of life. Pathogenic germline variants (PGVs) and its association to …

Adaptation behaviour is of critical importance to reduce or avoid negative impacts of climate
change. Many studies have examined which factors motivate individuals to adapt. However, …

Purpose: Mesenchymal stromal/stem cells (MSC) hold a great promise to control the imbalance
between anabolic and catabolic processes in an OA joint due to their immunomodulatory …

… The primary outcome was diabetes incidence, defined as fasting glucose ≥7.0 mmol/l
and/or 2 h glucose ≥11.1 mmol/l or registered as doctor diagnosed by self-report at follow-up …

Objectives: To evaluate the cost effectiveness of a systematic screening programme for
asymptomatic Chlamydia trachomatis infections in a female inner city population. To determine …

We investigated whether ethnic differences in handgrip strength, a marker of poor muscle
strength and quality, is a potential cause of ethnic disparities in type 2 diabetes mellitus. We …