SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions
One or more of the signaling lymphocytic activation molecule (SLAM) family (SLAMF) of cell
surface receptors, which consists of nine transmembrane proteins, ie, SLAMF1-9, are …
surface receptors, which consists of nine transmembrane proteins, ie, SLAMF1-9, are …
GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells
…, JR Regueiro, SB Berger, C Detre… - International …, 2010 - academic.oup.com
Naturally occurring regulatory T cells (Treg) express high levels of glucocorticoid-induced
tumour necrosis factor receptor (GITR). However, studies of the role of GITR in Treg biology …
tumour necrosis factor receptor (GITR). However, studies of the role of GITR in Treg biology …
Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency
…, G ElGhazali, A Fontana, S Pasic, C Detre… - Journal of Experimental …, 2010 - rupress.org
The contribution of B cells to the pathology of Omenn syndrome and leaky severe combined
immunodeficiency (SCID) has not been previously investigated. We have studied a mut/mut …
immunodeficiency (SCID) has not been previously investigated. We have studied a mut/mut …
Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function
…, M Baptista, CJ Moran, C Detre… - Blood, The Journal …, 2012 - ashpublications.org
The Wiskott-Aldrich syndrome protein (WASP) is a key cytoskeletal regulator of hematopoietic
cells. Although WASP-knockout (WKO) mice have aberrant B-cell cytoskeletal responses, …
cells. Although WASP-knockout (WKO) mice have aberrant B-cell cytoskeletal responses, …
A novel isoform of the Ly108 gene ameliorates murine lupus
Studies of human systemic lupus erythematosus patients and of murine congenic mouse
strains associate genes in a DNA segment on chromosome 1 with a genetic predisposition for …
strains associate genes in a DNA segment on chromosome 1 with a genetic predisposition for …
Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages
…, M Fresno, N Wang, C Detre… - The Journal of …, 2012 - journals.aai.org
Slamf8 (CD353) is a cell surface receptor that is expressed upon activation of macrophages
(MΦs) by IFN-γ or bacteria. In this article, we report that a very high NADPH oxidase (Nox2) …
(MΦs) by IFN-γ or bacteria. In this article, we report that a very high NADPH oxidase (Nox2) …
Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34 …
C Ma, N Wang, C Detre, G Wang, M O'Keeffe… - Journal of Biological …, 2012 - jbc.org
Phagocytosis is a pivotal process by which macrophages eliminate microorganisms upon
recognition by pathogen sensors. Surprisingly, the self-ligand cell surface receptor Slamf1 …
recognition by pathogen sensors. Surprisingly, the self-ligand cell surface receptor Slamf1 …
Rafting MHC-II domains in the APC (presynaptic) plasma membrane and the thresholds for T-cell activation and immunological synapse formation
Glycosphingolipid- and cholesterol-rich membrane microdomains (rafts) in T-cells are important
in triggering and regulation of T H -cell activation in immunological synapses (IS), which …
in triggering and regulation of T H -cell activation in immunological synapses (IS), which …
Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome
…, T Hickernell, T Paganini, KM Coakley, C Detre… - Proceedings of the …, 2010 - pnas.org
DNA ligase IV (LIG4) is an essential component of the nonhomologous end-joining (NHEJ)
repair pathway and plays a key role in V(D)J recombination. Hypomorphic LIG4 mutations in …
repair pathway and plays a key role in V(D)J recombination. Hypomorphic LIG4 mutations in …
Cholesterol sensitivity of detergent resistance: a rapid flow cytometric test for detecting constitutive or induced raft association of membrane proteins
Background Lipid rafts are cholesterol‐ and glycosphingolipid‐rich microdomains in the
cellular plasma membranes that play critical roles in compartmentalization (concentration, …
cellular plasma membranes that play critical roles in compartmentalization (concentration, …