Tobacco and alcohol use are leading causes of mortality that influence risk for many complex
diseases and disorders 1 . They are heritable 2 , 3 and etiologically related 4 , 5 behaviors …

Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …

Introduction Opioid-based analgesic therapy represents a cornerstone of pain management
after surgery. The recent rise in opioid sales and opioid overdoses suggests it is important to …

Background Variation in liability to cannabis use disorder has a strong genetic component (estimated
twin and family heritability about 50–70%) and is associated with negative …

There is a robust relationship between the experience of maltreatment in childhood and later
antisocial behaviors amongst adolescents and adults. Animal and human studies suggest …

OBJECTIVE: To review studies of adolescent substance use and abuse with genetically
informative designs. METHOD: Twin and adoption studies of adolescent substance use were …

Cannabis is a major substance of abuse, and the gene encoding for the central cannabinoid
receptor (CNR1) is a logical candidate gene for vulnerability toward developing symptoms …

This article reports on results of a one-day public health survey conducted in six states by
homeless youth providers to measure and compare risk factors between lesbian, gay, and …

BACKGROUND: One potential site of convergence of the nicotine and alcohol actions is the
family of the neuronal nicotinic acetylcholine receptors. Our study examines the genetic …

… project directed by Kathleen Mullan Harris and designed by J. Richard Udry, Peter S. Bearman,
… Hopfer assisted with the design of the study and wrote the first draft of the manuscript. …