… ruptured (chains B and C; boxed), adopting a state observed in desensitized structures (21).
(B) Top … In M2, chains A and D form an R dimer and chains B and C are desensitized (D). …

… Structural studies with γ2 suggest that TARPs preferentially occupy the B′D′ position (20).
Although not firmly established (26), type Ib-TARPs (γ4 and γ8) appear to preferentially …

AMPA receptors (AMPARs) are glutamate‐gated cation channels that mediate fast excitatory
neurotransmission and synaptic plasticity. Structures of GluA2 homotetramers in distinct …

The composition and spatial arrangement of subunits in ion channels are essential for their
function. Diverse stoichiometries are possible in a multitude of channels. These depend …

… In forebrain neurons GluA1/2 heteromers containing two TARP-γ8 subunits at their B/D sites
constitute a major AMPAR combination 27,28 , with variable possible interactions at the A′…

… B and D (Figure 3B). The carboxylate of E426 from one protomer interacts with the O-gamma
and N atoms of S431 from the other protomer, while N424 and A429 from each protomer …

… (B) Representative normalized current responses evoked by 100 ms glutamate application
(gray bars). Outside-out patches were pulled from cells transfected with GluA2iQ WT or Δ link …

… fitting to a two step model (A→B) in (a), whereas the process in (b) is better described by
a three steps model (A→B→C) (A, B and C are spectral species, reflecting distribution of …

… B, pH dependence of the k cat and k cat /K m S values for p-anisyl (● and ▾, respectively)
and 3-fluorobenzyl alcohol (○ and ▿, respectively) under saturating O 2 concentrations (air …

… Structural analysis of crystal packing revealed the presence of a hexamer A 3 B 3 (where
A and B are the two CaFADS chains of the crystallographic asymmetric unit, related by a …