in a superior intercostal space in individuals with high clinical suspicion (aborted sudden
cardiac death victims, family members of patients with Brugada syndrome) may also disclose …

Background—The congenital long-QT syndrome (LQTS) is caused by mutations on several
genes, all of which encode cardiac ion channels. The progressive understanding of the …

<p id="p001">Catecholaminergic polymorphic ventricular tachycardia is a potentially lethal
disease characterized by adrenergically mediated ventricular arrhythmias manifested …

Arrhythmogenic cardiomyopathy (ACM) is an arrhythmogenic disorder of the myocardium not
secondary to ischemic, hypertensive, or valvular heart disease. ACM incorporates a broad …

Background— The electrocardiographic short QT-interval syndrome forms a distinct clinical
entity presenting with a high rate of sudden death and exceptionally short QT intervals. The …

Mutations in SCN5A, the gene encoding the cardiac Na + channel, have been identified in 2
distinct diseases associated with sudden death: one form of the long-QT syndrome (LQT 3 ) …

BACKGROUND: Brugada syndrome (BrS) is a common heritable channelopathy. Mutations
in the SCN5A-encoded sodium channel (BrS1) culminate in the most common genotype. …

The J-wave syndromes (JWSs), consisting of the Brugada syndrome (BrS) and early
repolarization syndrome (ERS), have captured the interest of the cardiology community over the …

Fig. 1 Pedigrees and symptoms of the PCCD families. a, Pedigree of the French family.
Patients with an unknown status (stippled) were not included in the linkage study. Individuals …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal
inherited arrhythmia syndrome in which drug therapy is often ineffective. We discovered that …