Mutated isocitrate dehydrogenase 1 (IDH1) defines a molecularly distinct subtype of diffuse
glioma 1 , 2 – 3 . The most common IDH1 mutation in gliomas affects codon 132 and …

Hypoxic preconditioning provides protection against ischemic brain lesions in animal
models of cerebral ischemia–hypoxia. To analyze the underlying molecular mechanisms, we …

Purpose Evaluation of toxicity and efficacy of an alternating weekly regimen of temozolomide
administered 1 week on and 1 week off in patients with recurrent glioma. Patients and …

Importance Clinical outcomes for glioblastoma remain poor. Treatment with immune
checkpoint blockade has shown benefits in many cancer types. To our knowledge, data from a …

Background Glioblastoma is associated with a poor prognosis in the elderly. Survival has
been shown to increase among patients 70 years of age or younger when temozolomide …

Background Nearly all patients with newly diagnosed glioblastoma experience recurrence
following standard-of-care radiotherapy (RT) + temozolomide (TMZ). The purpose of the …

Brain extraction is a critical preprocessing step in the analysis of neuroimaging studies
conducted with magnetic resonance imaging (MRI) and influences the accuracy of downstream …

Purpose A randomized, phase III, placebo-controlled, partially blinded clinical trial (REGAL [Recentin
in Glioblastoma Alone and With Lomustine]) was conducted to determine the …

Background Optimal treatment and precise classification for anaplastic glioma are needed.
Methods The objective for long-term follow-up of NOA-04 is to optimize the treatment …

Background Effective treatments are needed to improve outcomes for high-grade glioma and
low-grade glioma. The activity and safety of dabrafenib plus trametinib were evaluated in …