Receptors on macrophages for the Fc region of IgG (Fc R) mediate a number of responses
important for host immunity. Signaling events necessary for these responses are likely …

Activation of macrophages by bacterial lipopolysaccharide (LPS) induces transcription of
genes that encode for proinflammatory regulators of the immune response. Previous work has …

Lyn-deficient mice were generated to analyze the role of Lyn in B cell antigen receptor (BCR)
signaling. These mice had a reduced number of peripheral B cells with a greater …

This study was undertaken to determine the incidence, risk factors, and in-hospital outcome
of nephropathy requiring dialysis (NRD) after percutaneous coronary intervention (PCI), and …

Toll-like receptors (TLRs) play prominent roles in initiating immune responses to infection, but
their roles in particular cell types in vivo are not established. Here we report the generation …

The mammalian gastrointestinal tract harbors thousands of bacterial species that include
symbionts as well as potential pathogens. The immune responses that limit access of these …

Macrophage Fcγ receptors (FcγRs) mediate the uptake and destruction of antibody-coated
viruses, bacteria, and parasites. We examined FcγR signaling and phagocytic function in …

Cross-linking of the B cell antigen receptor (BCR) leads to the activation of three types of
intracellular protein tyrosine kinases. These tyrosine kinases then phosphorylate signaling …

Toll-like receptors (TLRs) are sensors for the detection of invading infectious agents and
can initiate innate immune responses. Because the innate immune system induces an …

The contribution of Toll-like receptor (TLR) signaling to T cell-dependent (TD) antibody
responses was assessed by using mice lacking the TLR signaling adaptor MyD88 in individual …