Deep learning with differential privacy

M Abadi, A Chu, I Goodfellow, HB McMahan… - Proceedings of the …, 2016 - dl.acm.org
Machine learning techniques based on neural networks are achieving remarkable results in
a wide variety of domains. Often, the training of models requires large, representative …

Genomic classification of cutaneous melanoma

…, A Chevalier, L Chin, J Cho, RJ Cho, YL Choi, A Chu… - Cell, 2015 - cell.com
We describe the landscape of genomic alterations in cutaneous melanomas through DNA,
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …

[HTML][HTML] The molecular taxonomy of primary prostate cancer

…, AD Cherniack, S Chevalier, L Chin, J Cho, A Chu… - Cell, 2015 - cell.com
There is substantial heterogeneity among primary prostate cancers, evident in the spectrum
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …

Integrated genomic characterization of papillary thyroid carcinoma

…, AD Cherniack, D Cheung, L Chin, J Cho, A Chu… - Cell, 2014 - cell.com
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …

[HTML][HTML] Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

…, C Kandoth, R Akbani, H Shen, L Omberg, A Chu… - Cell, 2014 - cell.com
Recent genomic analyses of pathologically defined tumor types identify "within-a-tissue"
disease subtypes. However, the extent to which genomic signatures are shared across tissues …

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

…, X Wang, M Remke, X Wu, RYB Chiu, A Chu… - Nature, 2012 - nature.com
Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated
with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive …

Comprehensive molecular profiling of lung adenocarcinoma

…, JN Weinstein, DA Wigle, MD Wilkerson, A Chu… - Nature, 2014 - escholarship.org
Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we
report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, …

The somatic genomic landscape of chromophobe renal cell carcinoma

…, CC Fahey, KE Hacker, G Bhanot, DA Gordenin, A Chu… - Cancer cell, 2014 - cell.com
We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell
carcinomas (ChRCCs) on the basis of multidimensional and comprehensive characterization, …

Integrated genomic characterization of pancreatic ductal adenocarcinoma

…, J Shih, A Ally, M Balasundaram, R Carlsen, A Chu… - Cancer cell, 2017 - cell.com
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low …

Large-scale profiling of microRNAs for the cancer genome atlas

A Chu, G Robertson, D Brooks, AJ Mungall… - Nucleic acids …, 2016 - academic.oup.com
The comprehensive multiplatform genomics data generated by The Cancer Genome Atlas (TCGA)
Research Network is an enabling resource for cancer research. It includes an …