Glicocorticóides: Usos clássicos e emprego no tratamento do câncer

L Bavaresco, A Bernardi… - Infarma-Ciências …, 2005 - cff.emnuvens.com.br
Os glicocorticóides são hormônios esteróides, sintetizados no córtex da glândula adrenal,
que afetam o metabolismo dos carboidratos e reduzem a resposta inflamatória (GOODMAN & …

Formulation of lipid core nanocapsules

CG Venturini, E Jäger, CP Oliveira, A Bernardi… - Colloids and Surfaces A …, 2011 - Elsevier
Polymeric nanoparticle aqueous suspensions have been proposed as drug carriers to improve
the efficacy of medicines. Considering those nanocarriers, nanocapsules are vesicular …

[HTML][HTML] The role of short-chain fatty acids from gut microbiota in gut-brain communication

YP Silva, A Bernardi, RL Frozza - Frontiers in endocrinology, 2020 - frontiersin.org
A substantial body of evidence supports that the gut microbiota plays a pivotal role in the
regulation of metabolic, endocrine and immune functions. In recent years, there has been …

Anti-inflammatory effects of resveratrol: Mechanistic insights

…, MT Pacheco, RL Frozza, A Bernardi - International journal of …, 2018 - mdpi.com
Inflammation is the principal response invoked by the body to address injuries. Despite
inflammation constituting a crucial component of tissue repair, it is well known that unchecked or …

Free and nanoencapsulated curcumin suppress β-amyloid-induced cognitive impairments in rats: involvement of BDNF and Akt/GSK-3β signaling pathway

…, CM Oliveira, AB Meneghetti, A Bernardi… - Neurobiology of learning …, 2013 - Elsevier
Alzheimer’s disease (AD), a neurodegenerative disorder exhibiting progressive loss of memory
and cognitive functions, is characterized by the presence of neuritic plaques composed …

Characterization of trans-resveratrol-loaded lipid-core nanocapsules and tissue distribution studies in rats

RL Frozza, A Bernardi, K Paese… - Journal of …, 2010 - ingentaconnect.com
Several studies have reported that orally ingested trans-resveratrol is extensively
metabolized in the enterocyte before it enters the blood and target organs. Additionally, trans-…

Neuroprotective effects of resveratrol against Aβ administration in rats are improved by lipid-core nanocapsules

RL Frozza, A Bernardi, JB Hoppe, AB Meneghetti… - Molecular …, 2013 - Springer
Alzheimer’s disease (AD), a neurodegenerative disorder exhibiting a gradual decline in
cognitive function, is characterized by the presence of neuritic plaques composed of …

Sustained release from lipid-core nanocapsules by varying the core viscosity and the particle surface area

…, LM Colomé, JPU Pohlmann, A Bernardi… - Journal of …, 2009 - ingentaconnect.com
Based on the structure of polymeric nanocapsules containing a lipid-dispersed core composed
of caprylic/capric trygliceride (CCT) and sorbitan monostearate (SM), we hypothesized …

[HTML][HTML] Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model

A Bernardi, E Braganhol, E Jäger, F Figueiró… - Cancer letters, 2009 - Elsevier
Multimodal combinations of target agents with radiation and chemotherapy may enhance
cancer treatment efficacy; however, despite these treatments, gliomas recur early due to their …

Activity of LaSOM 65, a monastrol-derived compound, against glioblastoma multiforme cell lines

…, FB Mendes, E Braganhol, A Bernardi… - Anticancer …, 2013 - ar.iiarjournals.org
Background/Aim: Despite recent progress in glioblastoma treatment, prognosis is still poor.
Monastrol is a kinesin spindle protein (KSP) inhibitor and anticancer effects for this molecule …