The Canadian CT Head Rule for patients with minor head injury
…, K Vandemheen, C Clement, H Lesiuk, A Laupacis… - The Lancet, 2001 - thelancet.com
Background There is much controversy about the use of computed tomography (CT) for
patients with minor head injury. We aimed to develop a highly sensitive clinical decision rule for …
patients with minor head injury. We aimed to develop a highly sensitive clinical decision rule for …
Atrial fibrillation in patients with cryptogenic stroke
…, J Hall, H Vaid, M O'Donnell, A Laupacis… - … England Journal of …, 2014 - Mass Medical Soc
Background Atrial fibrillation is a leading preventable cause of recurrent stroke for which
early detection and treatment are critical. However, paroxysmal atrial fibrillation is often …
early detection and treatment are critical. However, paroxysmal atrial fibrillation is often …
An assessment of clinically useful measures of the consequences of treatment
A Laupacis, DL Sackett… - New England journal of …, 1988 - Mass Medical Soc
WITH neither the time nor the resources available to prevent, detect, or treat every disorder
in every patient, which preventive, diagnostic, or therapeutic interventions should take priority…
in every patient, which preventive, diagnostic, or therapeutic interventions should take priority…
Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study
Background The Randomized Aldactone Evaluation Study (RALES) demonstrated that
spironolactone significantly improves outcomes in patients with severe heart failure. Use of …
spironolactone significantly improves outcomes in patients with severe heart failure. Use of …
Evidence-based medicine: a new approach to teaching the practice of medicine
A NEW paradigm for medical practice is emerging. Evidence-based medicine de-emphasizes
intuition, unsystematic clinical experience, and pathophysiologic rationale as sufficient …
intuition, unsystematic clinical experience, and pathophysiologic rationale as sufficient …
How attractive does a new technology have to be to warrant adoption and utilization? Tentative guidelines for using clinical and economic evaluations
Because economic evaluations of health care services are being published with increasing
frequency it is important to (a) evaluate them rigorously and (b) compare the net benefit of …
frequency it is important to (a) evaluate them rigorously and (b) compare the net benefit of …
Bisphosphonate use and the risk of subtrochanteric or femoral shaft fractures in older women
Context Osteoporosis is associated with significant morbidity and mortality. Oral bisphosphonates
have become a mainstay of treatment, but concerns have emerged that long-term use …
have become a mainstay of treatment, but concerns have emerged that long-term use …
Prevalence, age distribution, and gender of patients with atrial fibrillation: analysis and implications
WM Feinberg, JL Blackshear, A Laupacis… - Archives of internal …, 1995 - jamanetwork.com
The prevalence of atrial fibrillation (AF) is related to age. Anticoagulation is highly effective in
preventing stroke in patients with AF, but the risk of hemorrhage may be increased in older …
preventing stroke in patients with AF, but the risk of hemorrhage may be increased in older …
Oral anticoagulants vs aspirin in nonvalvular atrial fibrillation: an individual patient meta-analysis
C van Walraven, RG Hart, DE Singer, A Laupacis… - Jama, 2002 - jamanetwork.com
ContextPatients with nonvalvular atrial fibrillation (AF) have an increased risk of stroke and
other vascular events.ObjectiveTo compare the risk of vascular and bleeding events in …
other vascular events.ObjectiveTo compare the risk of vascular and bleeding events in …
Users' guides to the medical literature: V. How to use an article about prognosis
CLINICAL SCENARIO You are about to see a 76-year-old retired schoolteacher for the
second time. You first saw her in the clinic a month ago because of cognitive problems. Your …
second time. You first saw her in the clinic a month ago because of cognitive problems. Your …
