Background Non-fatal outcomes of disease and injury increasingly detract from the ability of
the world's population to live in full health, a trend largely attributable to an epidemiological …

Background Improving survival and extending the longevity of life for all populations requires
timely, robust evidence on local mortality levels and trends. The Global Burden of Disease …

Although the role of Hedgehog (Hh) signalling in embryonic pattern formation is well
established 1 , its functions in adult tissue renewal and maintenance remain unclear, and the …

A key characteristic of stem cells and cancer cells is their ability to self-renew. To test if Wnt
signaling can regulate the self-renewal of both stem cells and cancer cells in the …

Background National levels of personal health-care access and quality can be approximated
by measuring mortality rates from causes that should not be fatal in the presence of …

We report the de novo folding of three hyperstable RNA tetraloops to 1–3 Å rmsd from their
experimentally determined structures using molecular dynamics simulations initialized in the …

Covid-19 in Immune-Mediated Inflammatory Diseases The authors describe patients in New
York City with known immune-mediated inflammatory disease in whom Covid-19 developed …

The worldwide pandemic of COVID-19, caused by the virus SARS-CoV,-2 has continued to
progress, and increasing information is becoming available about the incidence of digestive …

The monovalent ion parameters used by the AMBER-99 forcefield are shown to exhibit
physically inaccurate behavior in molecular dynamics simulations of strong 1:1 electrolytes. …

The United States Supreme Court ought to learn the facts about qualified immunity, the
judicially-created doctrine that often protects public officials from damages actions for the …