Epithelial cells are important building blocks of most tissues and the corner stone of tissue
architectures that allow directional transport of nutrients, ions and waste products in and out of …

W interference. In galectin-4–depleted HT-29 5M12 cells apical membrane markers accumulated
intracellularly. In contrast, basolateral membrane markers were not affected. Moreover, …

Individual cells in multicellular organisms constantly explore their microenvironment, or
niche, to obtain spatial information that is used to regulate cell behavior to maintain tissue …

Genome-wide association studies have identified thousands of SNPs associated with
predisposition to various diseases, including prostate cancer. However, the mechanistic roles of …

Genome-wide association studies (GWAS) have identified rs11672691 at 19q13 associated
with aggressive prostate cancer (PCa). Here, we independently confirmed the finding in a …

The sorting of newly synthesized membrane proteins to the cell surface is an important
mechanism of cell polarity. To identify more of the molecular machinery involved, we investigated …

RNA interference (RNAi) is a ubiquitous mechanism of eukaryotic gene regulation that can
be exploited for specific gene silencing. Retroviruses have been successfully used for stable …

Deep artificial neural network learning is an emerging tool in image analysis. We demonstrate
its potential in the field of digital holographic microscopy by addressing the challenging …

Simple Summary α6β4-integrins and plectin are the key structural components of
hemidesmosomes that have been implicated in carcinogenesis and which are thus considered as …

Galectins are a taxonomically widespread family of galactose-binding proteins of which
galectin-3 is known to modulate cell adhesion. Using single cell force spectroscopy, the …