Overview
- Recognized as an outstanding Thesis by the Department of Electrical and Computer Engineering, Seoul National University
- A comprehensive review of lab-on-a-chip based drug screening platforms
- Describes a novel approach to realize ‘pipetting-free’ high-throughput screening (HTS) platform for the widespread use of HTS
Part of the book series: Springer Theses (Springer Theses)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
About this book
This thesis demonstrates a technology that enables pipetting-free high-throughput screening (HTS) on a miniaturized platform, eliminating the need for thousands of one-by-one pipetting and conventional liquid handling systems. This platform enhances accessibility to HTS and enables HTS to be used in small-to-medium scale laboratories. In addition, it allows large-scale combinatorial screening with a small number of valuable cells, such as patients’ primary cancer cells. This technique will have a high impact for widespread use of HTS in the era of personalized medicine.
In this thesis, the author firstly describes the need and concept of ‘partipetting’ for pipetting-free HTS platform. It is realized by the one-step pipetting and self-assembly of encoded drug-laden microparticles (DLPs) on the microwells. Next, the technical implementations required for the platform demonstration are described. It includes preparation of encoded DLPs, plastic chip fabrication, andrealization of automated system. Lastly, screening of sequential drug combinations using this platform is demonstrated. This shows the potential of the proposed technology for various applications.
Similar content being viewed by others
Keywords
Table of contents (4 chapters)
Authors and Affiliations
About the author
Seo Woo Song earned PhD degree in the department of electrical and computer engineering from Seoul National University, Republic of Korea in 2019. His research interests are lab on a chip, bioMEMS, and micro-robotics.
Bibliographic Information
Book Title: One-Step Generation of a Drug-Releasing Microarray for High-Throughput Small-Volume Bioassays
Authors: Seo Woo Song
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-981-13-8094-5
Publisher: Springer Singapore
eBook Packages: Engineering, Engineering (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2019
Hardcover ISBN: 978-981-13-8093-8Published: 28 May 2019
Softcover ISBN: 978-981-13-8096-9Published: 14 August 2020
eBook ISBN: 978-981-13-8094-5Published: 13 May 2019
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XXI, 52
Number of Illustrations: 6 b/w illustrations, 40 illustrations in colour
Topics: Biomedical Engineering and Bioengineering, Microarrays, Soft and Granular Matter, Complex Fluids and Microfluidics, Nanotechnology and Microengineering, Applied Microbiology, Microengineering