The transcription factor Hand1 is required for cell-fate determination during placental development. Recent work shows that release of Hand1 from the nucleolus controls differentiation of trophoblast stem cells into trophoblast giant cells, and this switch is controlled by the antagonistic activities of HICp40 and Polo-like kinase-4 (Plk4).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Martindill, R. C. et al. Nature Cell Biol. 9, 1131–1141 (2007).
Habedanck, R., Stierhof, Y. D., Wilkinson, C. J. & Nigg, E. A. Nature Cell Biol. 7, 1140–1146 (2005).
Hudson, J. W. et al. Curr. Biol. 11, 441–446 (2001).
Firulli, A. B., McFadden, D. G., Lin, Q., Srivastava, D. & Olson, E. N. Nature Genet. 18, 266–270 (1998).
Riley, P., Anson-Cartwright, L. & Cross, J. C. Nature Genet. 18, 271–275 (1998).
Chen, C. M., Kraut, N., Groudine, M. & Weintraub, H. Cell 86, 731–741 (1996).
Thebault, S., Gachon, F., Lemasson, I., Devaux, C. & Mesnard, J. M. J. Biol. Chem. 275, 4848–4857 (2000).
Datta, A. et al. J. Biol. Chem. 279, 36698–36707 (2004).
Kalinichenko, V. V. et al. Genes Dev. 18, 830–850 (2004).
Firulli, B. A. et al. Mol. Cell 12, 1225–1237 (2003).
MacAuley, A., Cross, J. C. & Werb, Z. Mol. Biol. Cell 9, 795–807 (1998).
Wang, H., Ouyang, Y., Somers, W.G., Chia, W. & Lu, B. Nature 449, 96–101 (2007).
Elia, A. E., Cantley, L. C. & Yaffe, M. B. Science 299, 1228–1331 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tanenbaum, M., Medemao, R. Cell fate in the Hand of Plk4. Nat Cell Biol 9, 1127–1129 (2007). https://doi.org/10.1038/ncb1007-1127
Issue Date:
DOI: https://doi.org/10.1038/ncb1007-1127
